中草药提取物的体外抑菌活性研究  

Antimicrobial Activities of Traditional Chinese Materia Medica Extracts

作　　者：张显忠[1] 郭爱军[2] 李艳玲[1] 苗苗[1] 

机构地区：[1]泰山医学院,山东泰安271000 [2]泰安市中心医院,山东泰安271000

出　　处：《中华医院感染学杂志》2006年第5期563-565,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨10种中草药提取物的体外抗菌活性。方法制备10种中草药提取物,采用试管连续稀释法对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌和白色念珠菌进行体外抑菌试验。结果10种中草药的提取物对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌和白色念珠菌有不同程度的抑制活性;其中尤以赤芍、石榴皮、五味子和黄连的提取物抗耐药菌活性最高,赤芍提取物对上述4种菌的抑制活性均较高,其最低抑菌浓度(MIC)分别为7.80、1.95、1.957、.80 mg/ml。结论赤芍、石榴皮、五味子和黄连提取物呈现广谱抗菌特性,且具有抗耐药菌作用。OBJECTIVE To discuss the antimicrobial activity of extracts from 10 kinds of traditional Chinese materia medica （TCMM）in vitro. METHODS Extracts from 10 kinds of TCMM were prepared, and subjected to bacteriostatic tests in vitro by test tube continuously dilution in order to observe their minimal inhibitory concentration（MIC）, to Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. RESULTS Among the 10 kinds of TCMM extracts, which did have antimicrobial activity against S. aureus, E. coli, P. aeruginosa and C. albicans in different degree; among them, the antimicrobial activity of the extracts of Radix Paeoniae Rubra, Punica granatum, Schisandra chinensis and Coptis chinensis to resistant bacteria was the highest, the extracts of Radix Paeoniae Rubra showed strong inhibitory activities to the above 4 bacteria, especially to the resistant organisms with the MIC at 7.8, 1.95, 1.95 and 7.8mg/ml, respectively. CONCLUSIONS The extracts of Radix Paeoniae Rubra, P. granatum, S. chinensis and C. chinensis have broad spectrum of antimicrobial activity to resistant bacteria.

关 键 词：中草药 提取物 抗菌活性 最低抑菌浓度 

分 类 号：R222.19[医药卫生—中医基础理论]