轻度认知障碍的功能性神经影像学研究进展  

The progress of functional neuroimaging in the study of mild cognitive impairment

作　　者：李祖贵[1] 

机构地区：[1]天津医科大学总医院PET-CT中心,300052

出　　处：《国际放射医学核医学杂志》2006年第2期76-79,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：轻度认知障碍(MCI)是正常老化过程与早期阿尔茨海默病(AD)之间的一种中间过渡状态,具有进展为AD的高度危险性。功能性神经影像学手段(如PET、SPECT、fMRI脑显像)能对 MCI脑代谢、血流灌注特点进行正确评价,有助于AD的早期诊断、病程监测、疗效观察及临床治疗个体的选择。Mild cognitive impairment （ MCI ） represents a transitional state between healthy aging and very mild Alzheimer＇s disease. MCI patients have a substantially higher rate of progression to Alzheimer＇s disease compared with cognitively normal elderly people. Functional neuroimaging modalities, including PET. SPECT and functional MRI show that MCI patients have special abnormalities in brain metabolism and perfusion, so they can offer great value in the predicting cognitive decline and early diagnosis of dementia.

关 键 词：认知障碍 体层摄影术 发射型计算机 单光子 磁共振成像 功能性 阿尔茨海默病 

分 类 号：R749.1[医药卫生—神经病学与精神病学]