计算机辅助解析FTIR定量研究蛋白质构象的应用进展  

Developments of the Quantitative Study of Protein Conformation by FTIR and Computer-aided Analysis

作　　者：秦身钧[1] 王建滨[2] 姚宏伟[1] 史长林[1] 魏永巨[3] 

机构地区：[1]河北工程大学理学院,河北邯郸056038 [2]邯郸市质量技术监督局,河北邯郸056004 [3]河北师范大学化学与材料科学学院,河北石家庄050016

出　　处：《河北师范大学学报（自然科学版）》2006年第3期331-335,共5页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金资助项目(200153)

摘　　要：综述了计算机辅助解析傅里叶变换红外光谱在蛋白质构象定量研究中的应用进展,简要介绍了红外光谱测定及二阶导数谱、去卷积和曲线拟合等计算机数学处理方法.对已有的研究结果进行了分类总结,最后讨论了该领域中存在的问题和发展方向.Developments of the quantitative study of protein conformation by fourier transformation infrared spectroscopy （FTIR） and computer-aided analysis are reviewed. The FTIR mensuration and computer-aided analysis methods such as secondary derivative spectrum, deconvolution, curve fitting, are briefly introduced. The available experiments results are classified and summarized. Finally, the existing problems and development trends are discussed.

关 键 词：蛋白质构象 傅里叶变换红外光谱 二阶导数谱 去卷积 曲线拟合 

分 类 号：Q518.1[生物学—生物化学]