急性脑梗死病人血白细胞计数及血清IL-6的变化  

CHANGES OF LEUCOCYTE COUNTS AND LEVEL OF SERUM IL-6 IN PATIENTS WITH CEREBRAL INFARCTION

作　　者：袁海成[1] 王岭[1] 陈晶[1] 许波[1] 赵仁亮[2] 

机构地区：[1]青岛大学医学院第二附属医院神经科,山东青岛266042 [2]青岛大学医学院附属医院神经科

出　　处：《齐鲁医学杂志》2006年第3期219-220,222,共3页Medical Journal of Qilu

摘　　要：目的 探讨急性脑梗死病人血白细胞计数及血清IL-6水平的变化及其临床意义.方法 分别检测60例急性脑梗死病人（脑梗死组）急性期第1天白细胞计数及第1、3、7、14天血清IL-6水平,并与30例健康对照者（对照组）检测结果比较.结果 与健康对照组相比,脑梗死组病人血白细胞计数明显增高（t=7.826,P〈0.01）,血清IL-6水平在各时间点均高于对照组（t=9.797～31.768,P〈0.01）.大梗死灶脑梗死组病人血白细胞计数及血清IL-6水平高于中梗死灶病人组（F=4.25、4.07,q=2.847、3.685,P〈0.05）和小梗死灶病人组（q=2.976、3.563,P〈0.05）.重度脑梗死组病人血白细胞计数及血清IL-6水平均高于中度脑梗死组病人（F=5.657、5.463,q=4.457、5.628,P〈0.01）和轻度脑梗死组病人（q=5.036、5.312,P〈0.01）.结论 炎症反应可能是脑梗死病人急性期神经元损伤的原因之一;白细胞计数及血清IL-6水平的升高与疾病的严重程度有关,并可能成为疾病预后的判断依据.Objective To investigate the changes of leucocyte counts and the level of serum IL-6 in patients with cerebral infarction and their clinical significance. Methods The serum IL-6 was analysed with ELISA in 60 patients with cerebral infarction during different phases （on 1d, 3 d, 7 d and 14 d after the onset） and 30 healthy controls. Leucocytes of one day after the onset were counted in both groups. Results Compared with the healthy controls, both the number of leucocytes （t= 7. 826, P〈 0.0l） and the level of serum IL-6 （t=9. 797-31. 768,P〈0.01） of patients with cerebral infarction increased significantly. More leucocyte counts and higher level of serum IL-6 were detected in the large infarction group than in the moderate （F=4.25,4.02; q=2.847,3.685; P〈0.05） and small cerebral infarction group（q=2.976, 3.563; P〈0.05）. The number of the leucocyte and the levels of serum IL-6 in the severe cerebral infarction group increased significantly as compared with the moderate （F=5. 657, 5.463; q=4.457,5.628;P〈0. 01） and mild cerebral infarction groups （q=5. 036,5. 312, P〈0.01）. Conclusion Inflammatory reaction may be one of the common reasons of neuron injuries with acute cerebral infarction. The increase of leucocyte counts and the serum IL-6 may be related to the severity of disease process, and may be served as a parameter predicting the prognosis of the lesion.

关 键 词：脑梗死 白细胞计数 白细胞介素6 

分 类 号：R743.33[医药卫生—神经病学与精神病学]