The brassinosteroid signal transduction pathway  

作　　者：Zhi-Yong Wang Qiaomei Wang Kang Chong Fengru Wang Lei Wang Mingyi Bai Chengguo Jia 

机构地区：[1]Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA [2]Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China [3]Department of Horticulture,Zhejiang University, Hangzhou 310029, China

出　　处：《Cell Research》2006年第5期427-434,共8页细胞研究（英文版）

基　　金：This work was supported in part by grants from National Natural Science Foundation of China(No.30328004,No.30571269);National Institutes of Health(R01 GM66258-01).

摘　　要：Steroids function as signaling molecules in both animals and plants. While animal steroid hormones are perceived by nuclear receptor family of transcription factors, brassinosteroids （BR） in plants are perceived by a cell surface receptor kinase, BRI 1. Recent studies have demonstrated that BR binding to the extracellular domain of BRI 1 induces kinase activation and dimerization with another receptor kinase, BAKI. Activated BRI 1 or BAKI then regulate, possibly indirectly, the activities of BIN2 kinase and/or BSU 1 phosphatase, which directly regulate the phosphorylation status and nuclear accumulation of two homologous transcription factors, BZRI and BES 1. BZRI and BES 1 directly bind to promoters of BR responsive genes to regulate their expression. The BR signaling pathway has become a paradigm for both receptor kinase signaling in plants and steroid signaling by cell surface receptors in general.

关 键 词：BRASSINOSTEROID receptor kinase LRR-RLK GSK3 signal transduction ARABIDOPSIS 

分 类 号：Q51[生物学—生物化学]