云南高校图书馆联盟文献共享服务平台- GSK3

GSK3: 作品数：84被引量：423H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：马涛赵永波李燕胡海燕田丹更多>>; 相关机构：阿斯利康(瑞典)有限公司华中农业大学华中科技大学浙江大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金浙江省自然科学基金国家教育部博士点基金国家中医临床研究基地建设项目更多>>

基于PI3K/AKT/GSK3通路探讨三七总皂苷抑制大鼠肠缺血再灌注后血小板活化的作用机制: 《中医学报》2025年第3期642-647,共6页陈宇马腾关梓鹏徐佳; 中医养生学教育部重点实验室建设项目(2024-JYB-KYPT-02)。; 目的:观察三七总皂苷(panax notoginseng saponins,PNS)对大鼠肠缺血再灌注后血小板功能的影响,并基于磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,PKB,又称AKT)/糖原合成酶激酶-3(glycogen synt...; 关键词：三七总皂苷肠缺血再灌注损伤 PI3K/AKT/GSK3通路血小板活化

GSK3/Nrf2调控的生物节律在机体衰老中的规律: 《中国组织工程研究》2025年第6期1257-1264,共8页陈伊琳蒋晓波屈红林刘瑞莲; 江西省卫健委科技计划项目(SKJP202212703),项目负责人:陈伊琳;江西省教育厅科技计划项目(GJJ190873),项目负责人:陈伊琳。; 背景:生物节律(昼夜节律)紊乱是一个典型的与衰老有关的问题,维持生物节律的正常运作可能是一种很有前景的抗衰老策略。核转录因子NF-E2相关因子2的表达具有生物节律;糖原合成酶激酶3系统代表了一个“调节阀”,它控制核转录因子NF-E2相...; 关键词：糖原合成酶激酶3 核转录因子NF-E2相关因子2 生物节律衰老神经退行性疾病

抗结核新药与新方案年度进展2024: 《中华结核和呼吸杂志》2025年第2期170-175,共6页姚岚唐神结; 我国仍然是全球结核病高负担国家之一,估计每年发病患者为74.8万例,位列全球第三。面对“终止结核病策略”的要求,新药和新方案的研发是关键。目前已有多种新的抗结核药物处于临床试验阶段,如macozinone、sutezolid、alpibectir、GSK303...; 关键词：预防性治疗抗结核新药高风险人群利奈唑胺耐药问题耐药结核病抗结核药物 GSK3

甘松GSK3家族的鉴定及油菜素内酯对甘松生长发育的影响: 《中国中药杂志》2025年第2期395-403,共9页雷语妍马筝魏静李文兵李莹杨正明张绍山冯景秋盛华春刘圆; 国家重点研发计划项目(2018YFC1706101);四川省重点研发计划项目(2024YFFK0190);西南民族大学“双一流”项目(CX2023043);西南民族大学青藏高原研究第一批科技创新团队项目(2024CXTD04)。; 该文利用生物信息学的分析手段,共鉴定出8个甘松GSK3家族成员,包括NjBIN2。遗传进化树分析揭示甘松GSK3家族成员与拟南芥的亲缘关系更为接近。RT-qPCR结果显示NjBIN2在甘松的不同组织中具有特定的表达模式,其中在根部的表达量最高,表明...; 关键词：甘松 GSK3 BIN2 RT-QPCR

Genome-Wide Identification and Expression Analysis of the GSK3 Gene Family in Sunflower under Various Abiotic Stresses: 《Phyton-International Journal of Experimental Botany》2024年第8期1839-1850,共12页Xianwen Ji Ziying Jiang Jichao Wang Lili Dong Xinyi Deng; financed by the Anhui Provincial Central Leading Local Science and Technology Development Special Fund Project(202007d06020021);Project of Suzhou Science and Technology Bureau(2021143).; Genes in the glycogen synthase kinase 3(GSK3)family are essential in regulating plant response to stressful conditions.This study employed bioinformatics to uncover the GSK3 gene family from the sunflower genome datab...; 关键词：SUNFLOWER abiotic stress GSK expression analysis

Correction to:Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy: 《Journal of Molecular Cell Biology》2024年第8期58-58,共1页; This is a correction to:Yingmei Zhang,Rongjun Zou,Miyesaier Abudureyimu,Qiong Liu,Jipeng Ma,Haixia Xu,Wei Yu,Jian Yang,Jianguo Jia,Sanli Qian,Haichang Wang,Yang Yang,Xin Wang,Xiaoping Fan,Jun Ren,Mitochondrial aldehyd...; 关键词：mitochondrial integrity parkin mediated mitophagy diabetic cardiomyopathy aldehyde dehydrogenase GSK mitochondrial aldehyde dehydrogenase

小红参乙酸乙酯提取物调控PI3K/AKT/GSK3-β通路对心肌缺血再灌注损伤大鼠雌激素的影响被引量：2: 《河北医药》2024年第4期501-505,共5页张国庆周艳华王仙琪王佳佳; 国自然基金课题项目(编号:82201367)。; 目的研究小红参乙酸乙酯提取物通过调控磷脂酰肌醇3-激酶(phosphatidylinositol-3-OH kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)/糖原合成酶激酶3-β(glycogen synthase kinase 3-β,GSK3-β)通路对心肌缺血再灌注损伤大鼠雌激素...; 关键词：心肌缺血再灌注小红参乙酸乙酯雌激素磷脂酰肌醇3-激酶/蛋白激酶B/糖原合成酶激酶3-β

Glycogen synthase kinase 3 signaling in neural regeneration in vivo: 《Journal of Molecular Cell Biology》2023年第12期1-11,共11页Jing Zhang Shu-Guang Yang Feng-Quan Zhou; Glycogen synthase kinase 3(GSK3)signaling plays important and broad roles in regulating neural development in vitro and in vivo.Here,we reviewed recent findings of GSK3-regulated axon regeneration in vivo in both the ...; 关键词：GSK3 neural regeneration protein translation gene transcription

Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation: 《Cellular & Molecular Immunology》2023年第10期1127-1139,共13页Yubing Fu Jinjia Wang Chenfeng Liu Kunyu Liao Xianjun Gao Ronghan Tang Binbin Fan Yazhen Hong Nengming Xiao Changchun Xiao Wen-Hsien Liu; supported by the National Natural Science Foundation of China(31770953,81830047,and 81961138008 to CX and 32070877 to W-HL),1000 Young Talents Program of China(NX);the Fundamental Research Funds for the Central Universities of China-Xiamen University(20720170064 to CX).; Cellular immunity mediated by CD8+T cells plays an indispensable role in bacterial and viral clearance and cancers.However,persistent antigen stimulation of CD8+T cells leads to an exhausted or dysfunctional cellular ...; 关键词：GSK3 T-cell exhaustion Viral infection Anti-tumor immunity Inhibitory receptors

Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy被引量：2: 《Journal of Molecular Cell Biology》2023年第9期25-39,共15页Yingmei Zhang Rongjun Zou Miyesaier Abudureyimu Qiong Liu Jipeng Ma Haixia Xu Wei Yu Jian Yang Jianguo Jia Sanli Qian Haichang Wang Yang Yang Xin Wang Xiaoping Fan Jun Ren; supported in part by the State Key Laboratory of Dampness Syndrome of Traditional Chinese Medicine jointly established by Guangdong Province and the Ministry(SZ2022KF10);Scientific Research Initiation Project of Guangdong Provincial Hospital of Traditional Chinese Medicine(2021KT1709);Guangzhou School(College)Joint Sponsorship Project for Fundamental and Applied Research(202201020605);Program of Shanghai Academic/Technology Research Leader(20XD1420900).; Mitochondrial aldehyde dehydrogenase(ALDH2)offers proven cardiovascular benefit,although its impact on diabetes remains elusive.This study examined the effects of ALDH2 overexpression and knockout on diabetic cardiomy...; 关键词：ALDH2 diabetes MITOPHAGY cardiac contraction GSK3Β mitochondrial function

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