Objective To explore the association between aldehyde dehydrogenase 2(ALDH2)gene polymorphisms and abnormal liver function-induced by acetaminophen(APAP)drugs.Methods An ALDH2 gene knockout mouse model was constructed...
supported by grants from the National Nature Science Foundation of China(No.82172565,81620108022,81872245,91129303,991729302,81572759,,31900441,82003069,82103571,882002941,82072570,91129733,81502702).
Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate ...
supported by the State Key Program of the National Natural Science Foundation of China(82030059);the National Science Fund for Distinguished Young Scholars(82325031);the National Natural Science Regional Innovation Fund Joint Fund Key Support Projects(U23A20485);the National Natural Science Foundation of China(82072144,82172127);the National Key R&D Program of China(2020YFC1512700,2020YFC1512705,2020YFC1512703);the Key R&D Program of Shandong Province(2021ZLGX02,2021SFGC0503,2022ZLGX03);the Taishan Pandeng Scholar Program of Shandong Province(tspd20181220);the Taishan Young Scholar Program of Shandong Province(tsqn202211312);the Clinical Research Project of Shandong University(2021SDUCRCC006);the Interdisciplinary Young Researcher Groups Program of Shandong University(2020QNQT004).
Acetaldehyde dehydrogenase 2(ALDH2)mutations are commonly found in a subgroup of the Asian population.However,the role of ALDH2 in septic acute respiratory distress syndrome(ARDS)remains unknown.Here,we showed that hu...