Glycogen synthase kinase 3 signaling in neural regeneration in vivo  

作　　者：Jing Zhang Shu-Guang Yang Feng-Quan Zhou 

机构地区：[1]Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China

出　　处：《Journal of Molecular Cell Biology》2023年第12期1-11,共11页分子细胞生物学报（英文版）

摘　　要：Glycogen synthase kinase 3(GSK3)signaling plays important and broad roles in regulating neural development in vitro and in vivo.Here,we reviewed recent findings of GSK3-regulated axon regeneration in vivo in both the peripheral and central nervous systems and discussed a few controversial findings in the field.Overall,current evidence indicates that GSK3βsignaling serves as an important downstream mediator of the PI3K–AKT pathway to regulate axon regeneration in parallel with the mTORC1 pathway.Specifically,the mTORC1 pathway supports axon regeneration mainly through its role in regulating cap-dependent protein translation,whereas GSK3βsignaling might be involved in regulating N6-methyladenosine mRNA methylation-mediated,cap-independent protein translation.In addition,GSK3 signaling also plays a key role in reshaping the neuronal transcriptomic landscape during neuralregeneration.Finally,we proposed some research directions to further elucidate the molecular mechanisms underlying the regulatory function of GSK3 signaling and discover novel GSK3 signaling-related therapeutic targets.Together,we hope to provide an updated and insightful overview of how GSK3 signaling regulates neural regeneration in vivo.

关 键 词：GSK3 neural regeneration protein translation gene transcription 

分 类 号：R651[医药卫生—外科学]