尿多酸肽对乳腺癌细胞周期的影响  

Effect of Uroacitides on Cell Cycle Progression of Breast Cancer Cells

作　　者：郑伟[1] 马林[2] 陈凛[1] 李荣[1] 蒋彦永[1] 

机构地区：[1]解放军总医院普外科,北京100853 [2]解放军总医院放疗科,北京100853

出　　处：《中国普外基础与临床杂志》2006年第3期268-270,共3页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金项目(编号:30171066)~~

摘　　要：目的研究肿瘤细胞分化诱导剂尿多酸肽(CDAⅡ)对乳腺癌细胞周期的影响。方法将CDAⅡ与乳腺癌细胞株MCF7和MDA MB231进行体外培养,同时以维甲酸为阳性对照,观察其对乳腺癌细胞生长曲线、细胞周期、形态学等方面的影响。结果CDAⅡ可减缓两株乳腺癌细胞的生长和增殖能力,使乳腺癌细胞的细胞周期的分布出现S期比例减少,G0/G1期增加。结论CDAⅡ可抑制不同生物学特性的两株乳腺癌细胞的生长和增殖能力,细胞周期出现G0/G1期阻滞,为CDAⅡ治疗乳腺癌提供了实验依据。Objective To investigate the effect of CDA-Ⅱ on the cell cycle progression of breast cancer cells. Methods The effects of CDA-Ⅱ on growth curve, cell cycle progression and morphology of breast cancer cell lines MCF-7 and MDA-MB-231 were observed when CDA-Ⅱ and MCF-7 or CDA-Ⅱ and MDA-MB-231 were blended to cultivate in vitro, in comparison with the classical cell differentiation inducer ATRA. Results CDA-Ⅱ decreased the growth speed and inhibit proliferation ability in breast cancer cell lines MCF-7 and MDA-MB-231. It caused G0/ G1 phase block of cell cycle and reduced the rate of S phase of breast cancer ceils. Conclusion CDA-Ⅱ has remarkable effect of anti-cell-proliferation and can induce cell cycle block of G0/G1 on breast cancer cells. This results provide experimental bases for the treatment of breast cancer with CDA-Ⅱ.

关 键 词：乳腺癌 尿多酸肽 维甲酸 细胞周期 

分 类 号：R737.9[医药卫生—肿瘤]