多发性脑膜瘤的临床和组织学研究  

The clinical and histological study of multiple memingiomas

作　　者：孔军[1] 黄红光[2] 詹仁雅[2] Ralf Bu-hl 

机构地区：[1]青岛市市立医院神经外科,山东青岛266011 [2]浙江大学医学院附属第一医院神经外科,浙江杭州310003 [3]德国基尔大学医学院神经外科

出　　处：《医学研究生学报》2006年第5期451-453,共3页Journal of Medical Postgraduates

摘　　要：目的:研究多发性脑膜瘤的临床和组织学特点。方法:对39例多发性脑膜瘤的临床资料进行回顾性分析,免疫组化检测孕激素受体(PR)、p53和细胞周期蛋白抗体MIB-1在多发性脑膜瘤中的表达,并与单发性脑膜瘤进行比较。结果:多发性脑膜瘤女性多见,肿瘤的分布较为广泛,大脑半球凸面为好发部位。免疫组化结果显示:PR的表达在多发性脑膜瘤比单发性脑膜瘤强,p53和MIB-1的表达则两者无显著性差异。结论:多发性脑膜瘤的诊断主要依靠影像学资料,其发生学可能与孕激素及其受体有关,单克隆起源的可能性较大。Objective： To study the clinical and histological features of multiple meningiomas. Methods ： 39 cases of multiple meningiomas were analyzed retrospectively. The expressions of PR（ Progesterone receptor） , p53 and MIB-1 were detected by immunohistochemistry in the samples of multiple meningiomas and solitary meningiomas. Results ： Female predominance was obvious in cases of multipie meningiomas. The tumors had wide distributions with a main location in brain convexity. The results of immunohistochemistry showed stronger expression of PR and similar expression of p53 and MIB-1 in samples of multiple meningiomas than those in solitary meningiomas. Conclusion： The diagnosis of multiple meningiomas mainly depends on radiological examination. The pathogenesis of multiple meningiomas is probably related to progesterone and its receptor, and it is most likely monoclonal origin.

关 键 词：多发性脑膜瘤 诊断 组织学 孕激素受体 

分 类 号：R739.45[医药卫生—肿瘤]