实验性骨质疏松症对下颌骨骨折愈合的影响  

The bone histomorphometry study of the effect of experimental osteoporosis to the fracture healing of mandible

作　　者：王大维[1] 董福生[2] 闫宝勇[1] 王洁[2] 石培凯[2] 董玉英[2] 

机构地区：[1]河北医科大学第一医院口腔科,石家庄050031 [2]河北医科大学口腔医学院

出　　处：《现代口腔医学杂志》2006年第3期281-283,共3页Journal of Modern Stomatology

基　　金：河北省自然基金资助项目(编号:300359)

摘　　要：目的 建立骨质疏松大白兔模型，探讨骨质疏松对下颌骨骨折愈合的影响，为临床提供理论依据。方法 38只3～4月龄雌性新西兰大白兔，随机分为实验组（去势组）及对照组（假手术组）。实验组去除双侧卵巢，对照组只摘除卵巢周围部分脂肪。建模成功后，两组均于双侧颌下角前切迹处行双侧下颌骨骨折，术后2、4、8用处死动物，取骨折处骨痴进行组织学及骨组织形态计量学研究。结果 实验组各时同点的愈合均较对照组慢，骨组织形态计量学比较有显著性差异（P〈0．05）。结论 骨质疏松性骨折的愈合过程较正常骨折愈合慢。愈合后仍处于骨质疏松状态。Objective To investigate the effect of the osteoporosis to the healing process of the mandible fracture. Methods Three - to four - month - old New Zealand female rabbits, weighing approximately 3 -3,5Kg, were selected to establish the osteoporotic animal model by ovariectomy and 0.15 % low- calcium diet. The osteoporosis was confirmed in two months post operation. All the rabbits were made bilateral mandible fracture at the border of the mandible. The rabbits were sacrificed at 2,4,8 week post fracture and six rabbits were in each group, The mandibles were obtained for histological and bone histomorphometry examination,Results The histological and bone histomorphometry examinations demonstrated that the difference in the area of unite callus and cartilage callus at the 2 and the 4 week was significant （ P 〈0,05）.Concluslon The healing process of osteoporosis fracture was slower than that of the normal fracture, after healing, the bone was still i osteoporosis.

关 键 词：骨质疏松 骨组织形态计量学 下颌骨 骨折愈合 去势 

分 类 号：R782[医药卫生—口腔医学]