β-连环素和E-钙粘素在肝细胞癌中的表达及意义(英文)  

β-catenin and E-cadherin expression in hepatocellular carcinoma and clinicopathological significance

作　　者：鞠新华[1] 魏林[1] 夏振龙[1] 

机构地区：[1]中国医科大学附属第二医院普外科,辽宁沈阳110004

出　　处：《中国现代医学杂志》2006年第9期1285-1287,1293,共4页China Journal of Modern Medicine

摘　　要：目的探讨β-连环素与E-钙粘素在肝癌中的表达及与临床病理学的意义。方法采用S-P免疫组化法检测β-连环素及E-钙粘素在72例肝癌的表达。结果在肝癌中β-连环素(76.4%)和E-钙粘素异常表达(61.1%)均明显高于癌周组织与肝硬化(P<0.001)。β-连环素或E-钙粘素异常表达在肝癌中分化呈明显相关(P<0.001)。E-钙粘素异常表达在门静脉有无癌栓中呈明显相关(P<0.01)。结论β-连环素与E-钙粘素异常表达可能参与肝癌发生、发展,并与肝癌的临床生物特性有一定关系。[Objective] To investigate the expression of β-catenin and E-cadherin and the clinicaopathological significance in hepatic cancer. [Methods] β-catenin and E-cadherin expressions in 72 patients with hepatic cancer were detected byimmunohistochemical method. [Results] The abnormal expression β-catenin（76.4%） and E-cadherin（61.1%） in hepatic cancer was significantly higher than that in paracancer and liver cirrhosis （P ＜0.001）. The abnormal expression of β-catenin and E-cadherin showed significant relationship with differentiation grade （P ＜0.001）. The abnormal expression of E-cadherin significantly was related with portal vein embolus or not （P ＜0.01）.[ Conclusions ] The β-catenin and E-cadherin may participate in the process of development, progression in hepatic cancer. The abdominal expression of β-catenin and E-cadherin is related with biological characteristic of hepatic cancer.

关 键 词：Β-连环素 E-钙粘素 肝细胞癌 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]