急性缺氧对人体血清中瘦素水平的影响  

Effect of Acute Hypoxia on Serum Leptin Level in Human

作　　者：陈云天[1] 胡颖[1] 张雪峰 张梅 格日力[1] 

机构地区：[1]青海大学高原医学研究中心,青海西宁810001 [2]格尔木市人民医院,青海格尔木816000

出　　处：《环境与健康杂志》2006年第3期231-232,共2页Journal of Environment and Health

摘　　要：目的探讨人体在急性缺氧状态下体内瘦素(leptin)水平的变化。方法以来自平原地区,经体检证实身体健康的34名汉族男性登山队员为研究对象。按测量地区海拔不同,将研究对象分为2800m组(7人)和5050m组(27人)。当登山队员进入海拔2800m和5050m地区24h后,于清晨空腹采取肘部静脉血10ml,4000r/min离心20min,分离到的血清置于液氮中保存。采用放射免疫法和由中科院协和技术公司提供的试剂盒,由专业技术人员测定血清中的leptin含量。同时采用美国Datex-Ohmeda公司生产的Tuffsat脉搏血氧饱和度监护仪测量队员的动脉血氧饱和度(SaO2)。结果5050m组血清中leptin水平为(9.08±7.77)ng/ml,高于2800m组犤(2.02±1.09)ng/ml犦;5050m组SaO2为70.85%±11.64%,低于2800m组(90.14%±2.54%),差异均有统计学意义(均P<0.01)。结论急性缺氧可刺激人体血清中leptin水平升高。Objective To understand the change of leptin level in human in acute hypoxia state. Methods 34 male moun ＇taineers were examined, 7 at the altitude of 2 800 m, 27 at 5 050 m. The serum leptin level and anoxic degree were, determined by radioimmunoassay and arterial oxygen saturation were determined by Tuffsat arterial oxygen saturation monitor. Results The leptin level at 5 050 m [（9.08±7.77） ng/ml] was significantly higher than that at 2 800 m[（2.02±1.09） ng/ml], P〈0.001, while arterial oxygen saturation at 5 050 m（70.85%±11.64%） was significantly lower compared with that at 2 800 m（90.14%±2.54%）, P〈0.001. Conclusion Acute hypoxia can greatly increase the serum leptin level in human.

关 键 词：缺氧 瘦素 高原 

分 类 号：R122.2[医药卫生—环境卫生学]