大豆异黄酮对去势大鼠骨代谢的影响  

Effects of soybean isoflavones on bone metabolism in ovariectomized rats

作　　者：潘喜华[1] 仲伟鉴[1] 肖萍[1] 杨隽[1] 施志冲[1] 董竟武[1] 郑勇英[1] 

机构地区：[1]上海市疾病预防控制中心,上海200336

出　　处：《上海预防医学》2006年第5期211-212,221,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的]探讨大豆异黄酮改善激素缺乏大鼠骨营养状况及作用机制。[方法]选用卵巢切除大鼠所诱发的骨质疏松模型,给予大豆异黄酮治疗,同时设假手术组及模型对照组。3个月后测定大鼠骨密度、骨钙含量及骨代谢酶学指标。[结果]大豆异黄酮可提高去势大鼠的骨密度、骨钙含量;降低血清碱性磷酸酶(AKP)及抗酒石酸酸性磷酸酶(TRACP)的活性(P<0.05),其作用与剂量有关。[结论]大豆异黄酮能够增加去势大鼠的骨密度,有类似雌激素样作用,可有效防治卵巢切除大鼠的骨量丢失,其作用机制可能是通过降低骨转换率来实现。[ Objective ] To study the preventive effects of soybean isoflavones on reduction of bone mass in ovariectomized rats. [ Methods] Ovariectomized rats were given soybean isoflavones to protect them from bone mass loss. Meantime the sham operation group and model control group were established. Bone mineral density （BMD） , calcium content and bone metabolism - associated biochemical markers were measured in 3 month. [ Results] Soybean isoflavones increased BMD and calcium content of femur in the ovariectomized rats. The activities of serum alkaline phosphatase （AKP） and tartrate - resistant acid pbosphatase （TRACP）were lower in the isoflavones -fed rats compared with model control group. [ Conclusion] Soybean isoflavones might exert estrogen - like effect in ovariectomized rats, isoflavones was effective in preventing bone mass loss induced by ovariectomy. Our findings suggest that the effects of isoflavones may be partly by slowing down the ovariectomy - induced higher rates of bone turnover.

关 键 词：大豆异黄酮 去卵巢大鼠 骨密度 骨质疏松 

分 类 号：R285[医药卫生—中药学]