液基细胞学应用于宫颈癌筛查的临床研究  

Study on Cervix Carcinoma Screening with Liquid-based Cytology Test

作　　者：李晓强[1] 郭建华[1] 朱名安[1] 王凤婕[1] 王元元[1] 

机构地区：[1]郧阳医学院附属太和医院检验部,湖北十堰442000

出　　处：《郧阳医学院学报》2006年第2期84-86,共3页Journal of Yunyang Medical College

摘　　要：目的:评价液基细胞学(th inprep cytology test,TCT)薄片制片对宫颈癌筛查的准确性。方法:采用TCT制片及传统宫颈细胞涂片法分别对2 246例、2 635例受检者进行宫颈癌筛查。细胞诊断采用TBS分级系统,所有意义不明的不典型鳞状上皮(ASCUS)以上病变的受检者全部在阴道镜下活检。结果:TCT薄片法和传统巴氏涂片法对低度鳞状上皮内病变(LSIL)以上病变的检出率分别为4.1%、1.56%,两者结果差异有显著性意义(P<0.01)。Th inPrep液基细胞学检出LSIL、高度鳞状上皮内病变(HSIL)、鳞状细胞癌(SCC)与阴道镜活检阳性符合率分别为81.82%、90.91%、100%。传统宫颈巴氏涂片法检出LSIL、HSIL、SCC与阴道镜活检阳性符合率分别为55.17%、55.56%、100%。两种方法比较差异有显著性意义(P<0.05)。结论:Th inPrep液基细胞学检查敏感性明显高于传统宫颈细胞涂片法,能大大提高检出率,尤其是对LSIL和HSIL的患者。Objective To evaluate the efficacy of liquid - based cytology test for screening cervix carcinoma. Methods 2246 and 2635 patients were screened for cervical carcinoma with TCT and traditional cervical cells smears respectively. Cell diagnosis adopted TBS - group system, aU the subjects of above - ASCUS pathological changes were examined with colposcope. Results The above - LISL pathological changes identified by TCT and traditional smears were 4.1% and 1.56 % respectively. There was significant difference between them （ P 〈 0.01 ）. The detection rates by TCT and traditional cervical cells smears were all 100% for SCC, 90.91% and 55.56% for HSIL, and 81.82% , 55.17% for LSIL. There was distinct difference between them （ P 〈 0.05 ）. Conclusion TCT is more sensitive than traditional cervical cells smears . Liquid - based cytology can improve the detection rate of LSIL in cervical screen, especially in LISL and HSIL.

关 键 词：宫颈癌 液基细胞学 TBS诊断 

分 类 号：R737.33[医药卫生—肿瘤]