自发性脑出血患者血清基质金属蛋白酶-9及其抑制因子水平的研究  

Investigation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase in patients with spontaneous intracerebral hemorrhage

作　　者：王珊[1] 史福平[1] 张国华[1] 张林静[1] 尹晶[1] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000

出　　处：《中国综合临床》2006年第6期500-502,共3页Clinical Medicine of China

基　　金：河北省自然科学基金资助项目(C2005000748);河北省卫生厅医学科学研究重点课题计划资助项目(04049)

摘　　要：目的研究自发性脑出血患者血清基质金属蛋白酶9(MMP9)及其抑制剂水平与脑水肿体积的关系。方法采用酶联免疫吸附法对30例24h内入院的脑出血患者血清MMP9和组织抑制因子1(TIMP1)水平进行测定,与正常对照组进行比较,并对患者进行神经功能评分,根据头部CT扫描所示计算血肿周围水肿(PHE)体积。结果脑出血患者血清MMP9及TIMP1水平较正常对照组明显升高[脑出血组分别为(107.60±49.47)μg/L、(385.99±97.22)μg/L;正常对照组分别为(57.15±40.67)μg/L、(298.27±78.61)μg/L;均为P<0.05],基底节区出血组MMP9的含量与CT所示出血灶周围水肿区体积呈显著正相关(r=0.705,P<0.01)。结论脑出血患者血清MMP9及TIMP1代谢异常,血清MMP9水平可反映脑出血患者血肿周围水肿严重程度,对其含量测定有助于判断病情。Objective To study the serum levels of matrix metaUoproteinase-9 （MMP-9） and tissue inhibitor of metaUoproteinase （TMP-1） in patients with spontaneous intraeerebral hemorrhage （ ICH ） and the relationship between the level of MMP-9 and the edema volume. Methods MMP-9 and TIMP-1 were determined by enzyme- linked immunosorbent assay in 30 ICH patients who were admitted within 24 h. Neurologie score was measured on admission. Perihematomal edema volumes were measured aeeording to CT sean. Results Serum levels of MMP-9 and TIMP-1 were higher in ICH patients than in normal control [ （ 107.60 ± 49.47 μg/L, （ 385.99 ± 97.22 ） μg/L vs （57.15 ±40.67）μg/L,298.27 ±78.61 μg/L,P 〈 0.05 for each] ,serum levels of MMP-9 in the basal ganglia hemorrhage group were positively correlated with perihematomal edema volume （ r = 0.705 ,P 〈 0.01 ）. Conclusion There is the abnormal metabolism of MMP-9 and TIMP-1 in ICH patients. Serum MMP-9 level may refleet the severity of perihematomal edema and is helpful to the judgment of its contents.

关 键 词：脑出血 基质金属蛋白酶-9 组织抑制因子-1 脑水肿 自发性脑出血 

分 类 号：R743.34[医药卫生—神经病学与精神病学]