^(99)Tc^m-HL91肺显像与非小细胞肺癌恶性程度的相关性  

The relationship between ^(99)Tc^m-HL91 imaging and NSCLC malignant grade

作　　者：武新宇[1] 刘保平[1] 谢新立[1] 

机构地区：[1]郑州大学第一附属医院核医学科,郑州450052

出　　处：《中原医刊》2006年第10期22-23,共2页Central Plains Medical Journal

摘　　要：目的探讨99Tcm-HL91(4,9-二氮-2,3,10,10-四甲基十二烷-2,11-二酮肟)显像与肺癌恶性程度的关系。方法35例非小细胞肺癌患者,注射99Tcm-HL91,4 h后行胸部前后位、后前位平面及断层显像,利用感兴趣区技术,计算肿瘤与对侧正常组织的放射性比值(T/N)。患者均行细胞学检查,标本做HE染色。结果99Tcm-HL91平面显像:30例显像阳性;断层显像:33例显像阳性。断层显像4 h的T/N比值显著高于平面像的T/N比值(t=10.619,P=0.000);HL91显像的T/N比值与肺癌细胞恶性程度相关(r=0.626,P=0.000)。结论HL91显像的T/N比值与肺癌细胞恶性程度呈中度正相关。HL91显像可以用来预测肿瘤恶性程度。Objective To evaluate the ability of ^99Tc^m-HL91 imaging in characterising the non-small-cell lung cancer （NSCLC） malignant grades. Methods Thirty-five patients with NSCLC, performed SPECT and anteroposterior, posteroantefior chest planar imagings at 4 hour after injection of ^99Tc^m-HL91. ROIs were drawn in imagings of tumor and symmetry in lung planar scan, and the radioactivity ratios tumor-to-normal tissue（T/N） were calculated. All patients were operated and the samples were for HE staining. Results Planar imaging：^99Tc^m-HL91 was showed visible uptake in 30 out of 35 patients. SPECT imaging： 33 out of 35 were positive. The difference of T/N between planar imaging and SPECT was significant （ t=10.619, P=0. 000）. And uptake of ^99Tc^m-HL91 was related to the malignancy of the cancer cell（ r=0.626, P = 0.000）. Conclusion Uptake of HL91 was correlated to the malignancy of the cancer cell. HL91 imaging may serve as an atraumatic method in predicting the malignancy of the cancer cell.

关 键 词：非小细胞肺癌 核素显像 HL91 ^99MTC 

分 类 号：R734.2[医药卫生—肿瘤] R730.264[医药卫生—临床医学]