Electrochemotherapy for rat implanted liver tumour  

作　　者：SHAO Cheng-wei TIAN Jian-ming WANG Pei-jun ZUO Chang-jing ZHANG Huo-jun 

机构地区：[1]Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

出　　处：《Chinese Medical Journal》2006年第8期696-700,共5页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China (No. 30500137) .

摘　　要：The most common interventional therapies for liver cancer at present include transcatheter hepatic arterial chemoembolization （TACE）, percutaneous ethanol injection and radiofrequency ablation, but all these therapies have some intrinsic disadvantages. Since the advent of electrochemotherapy （EChT）, it has been accepted as a safe and effective therapy for malignant tumors There are only a few experimental studies reporting the use of EChT in the treatment of liver cancer in the foreign medical literature. However, there have been some clinical studies, and even fewer reports of experimental studies on EChT for liver cancer in China. We used a rat implanted liver cancer animal model to monitor changes in tumour size, tumour necrosis, cellular apoptosis, expression of peripheral immunological markers （IL-2, slL-2R, IL-6 and TNF-α） and survival.The most common interventional therapies for liver cancer at present include transcatheter hepatic arterial chemoembolization （TACE）, percutaneous ethanol injection and radiofrequency ablation, but all these therapies have some intrinsic disadvantages. Since the advent of electrochemotherapy （EChT）, it has been accepted as a safe and effective therapy for malignant tumors There are only a few experimental studies reporting the use of EChT in the treatment of liver cancer in the foreign medical literature. However, there have been some clinical studies, and even fewer reports of experimental studies on EChT for liver cancer in China. We used a rat implanted liver cancer animal model to monitor changes in tumour size, tumour necrosis, cellular apoptosis, expression of peripheral immunological markers （IL-2, slL-2R, IL-6 and TNF-α） and survival.

关 键 词：liver neoplasms ELECTROCHEMOTHERAPY therapeutic effects 

分 类 号：R735.7[医药卫生—肿瘤]