TGF-α和EGFR在Barrett食管和食管腺癌的表达  

Expression of transforming growth factor alpha and epidermal growth factor receptor in Barrett's esophagus and esophageal adenocarcinoma

作　　者：呼闯营[1] 贺彩峰[1] 

机构地区：[1]苏州大学附属第二医院消化科,江苏省苏州市215004

出　　处：《世界华人消化杂志》2006年第9期879-883,共5页World Chinese Journal of Digestology

摘　　要：目的:研究Barrett食管和食管腺癌中TGF-α和 EGFR的表达意义．方法:采用免疫组化SABC法检测反流性食管炎13例、Barrett食管17例和食管腺癌11例中 TGF-α和EGFR的表达,并以30例正常食管黏膜为对照,运用免疫组化图像分析加以定量, 进行统计学的分析和比较．结果:TGF-α和EGFR在正常食管黏膜、反流性食管炎、Barrett食管和食管腺癌的表达逐渐增高,二者呈明显的正相关(r=0．951, P<0．01);TGF-α主要表达于细胞质,EGFR在正常食管黏膜和反流性食管炎表达于细胞膜, 而在Barrett食管非典型增生和食管腺癌,则可见细胞质和细胞核的明显表达．结论:TGF-α和EGFR在反流性食管炎、 Barrett食管和食管腺癌中表达逐渐增高并且相互作用,可能对Barrett食管和食管腺癌的发生、发展起一定的作用．AIM： To investigate the expression of transforming growth factor alpha （TGF-α） and epidermal growth factor receptor （EGFR） in Barrett＇s esophagus and esophageal adenocarcinoma. METHODS： Immunohistochemistry （SABC assay） was used to detect the expression of TGF-α and EGFR protein in patients with reflux esophagitis （n = 13）, Barrett＇s esophagus （n = 17）, esophageal adenocarcinoma （n = 11） and normal esophageal mucosa （n = 30）. RESULTS： In the development of reflux esophagifts, Barrett＇s esophagus and esophageal adenocarcinoma, the expression of TGF-α and EGFR protein increased gradually and closely correlated with each other （r = 0.951, P 〈 0.01）. TGF-α protein was mainly expressed in the cytoplasm. EGFR was expressed in the cellular membrane in the normal esophageal mucosa and reflux esophagitis, but strongly positively expression was also observed in the cytoplasm and nucleus of cells in Barrett＇s esophagus with dysplasia and esophageal adenocarcinoma. CONCLUSION： TGF-α and EGFR expression increase and may play synergic roles in the development of Barrett＇s esophagus and esophageal adenocarcinoma.

关 键 词：转化生长因子Α 表皮生长因子受体 BARRETT食管 食管腺癌 

分 类 号：R571[医药卫生—消化系统] R735.1[医药卫生—内科学]