移动电话微波辐射对二甲基苯蒽诱发大鼠乳腺癌的影响  

Effects of mobile-phone microwave on dimethylbenz(a)anthracene induced mammary carcinoma development in rats

作　　者：沈永浩[1] 鱼达[1] 傅一提[1] 姜槐[1] 

机构地区：[1]浙江大学医学院浙江省生物电磁学重点研究实验室,杭州310031

出　　处：《中华预防医学杂志》2006年第3期164-167,共4页Chinese Journal of Preventive Medicine

摘　　要：目的研究900MHzGSM微波辐射对二甲基苯并蒽(DMBA)诱发的SD大鼠乳腺癌是否有促进作用。方法500只大鼠按体重分为5个实验组,并按35mg/kg体重1次性灌胃给予DMBA。其中,1组为不给予辐照的空白对照组,其余4组的900MHzGSM微波辐照剂量为双盲,比吸收率值分别为:0(假辐照)、0.44、1.33和4.00W/kg。微波辐照开始于给予DMBA后第2天,持续26周,每周辐照5次,每次持续4h,在辐照全部结束后第3至第7天中处死动物,进行病理学和肿瘤发生学研究。结果假辐照组大鼠乳腺癌的发生率为37%(37/100);辐照剂量分别为0.44、1.33和4.00W/kg的各组大鼠乳腺癌发生率分别为25%(25/100)、34%(34/99)和38%(38/100),与假辐照组比较,均差异无统计学意义。病理组织形态学观察可见,该模型的乳腺肿瘤有恶性与良性两类,恶性肿瘤有乳腺腺癌和鳞状细胞癌,良性肿瘤有腺瘤、纤维腺瘤和乳腺囊肿。有时几种病理形态可同时出现在1个个体中,其组织病理表现呈多样性。结论在本实验条件下,900MHz的GSM微波辐射对DMBA诱发大鼠乳腺癌的发生无促进作用。Objective To investigate whether exposure to 900 MHz GSM wireless communication signals enhances mammary tumor development and growth induced by low dose dimethylbenz（a） anthracene （DMBA）. Methods Five hundred female Sprague Dawley （SD） rats were treated with a single dose of 35 mg/kg. DMBA and then divided into 5 groups： one control group without exposure, and 4 groups with exposure in blinded fashion. The specific absorption rates （SAR） were 0, 0. 44, 1.33 and 4. 00 W/kg for the 4 exposure groups, respectively. Exposure started on the next day after DMBA administration and lasted 4 hours/day, 5 days/week for 26 weeks. Rats were weighted and palpated weekly for the presence of tumors, and killed at the end of 26-week exposure period. All mammary glands were examined histopathologieally. Results The incidence of mammary carcinoma in sham-exposure group was 37% （37/100）. And mammary carcinoma incidences in the other groups of the exposure dose （0.44, 1.33 and 4.00W/kg） were 25% （25/100）, 34% （34/99）and 38% （38/100）respectively. There were no statistically significant differences between sham- and mobile phone microwave-exposed groups. In addition, the histopathological morphology of mammary tumor model in SD rats was observed. By microscopical examination two types of mammary tumor in this model were found, that was malignant or benign one. The former included adenocarcinoma and squamous cell carcinoma, and the latter included adenoma, fibroadenoma and cyst. Sometimes the hiatopathological morphology of mammary tumor appeared various since several kinds of histopathological features existed in the same individual. Conclusion This study does not provide the evidence that 900 MHz GSM microwave exposure might promote DMBA-induced mammary tumor development in rats.

关 键 词：微波 苯并蒽类 乳房肿瘤 实验 移动电话 

分 类 号：R737.9[医药卫生—肿瘤] R594.8[医药卫生—临床医学]