葡萄糖和电解质对全肠外营养液中pH值和微粒稳定性影响的观察  

Effects of glucose and electrolytes on the stability of pH value and micro-particles in the total parenteral nutrient solution

作　　者：杨晓军[1] 钟智[1] 陈赛红[1] 吴万征[1] 吴雪梅[1] 

机构地区：[1]广东医学院附属医院药剂科,广东湛江524001

出　　处：《广东医学院学报》2006年第2期127-128,133,共3页Journal of Guangdong Medical College

摘　　要：目的:观察葡萄糖、电解质和pH值对全肠外营养液(TPN)稳定性的影响。方法:5组不同浓度葡萄糖及电解质的TPN液,配制后放置于19℃~21℃中贮存,并于0、5、10、15、24 h时分别取样,测定溶液pH值、溶液微粒数并肉眼观察其外观变化。结果:0 h^24 h组1~组5 TPN液pH值的变化在0.06范围内;≥5μm的微粒数(24 h内的平均数)组5与组1~组4比较差异有非常显著性(P<0.01);5组TPN液外观均未出现明显变化。结论:葡萄糖和1价电解质的常用量对TPN液稳定性影响较小,而2价电解质对TPN液稳定性影响较大,故在配制时应注意电解质用量,尤其是2价电解质。Objective： To investigate the effect of glucose and electrolytes on the stability of pH value and micro-particles in the total parenteral nutrient（TPN） solution. Methods： The pH value and number change of microparticles from 5 groups of TPN sample solutions with different concentration of glucose and electrolytes were determined at 0, 5, 10, 15, 24 hours, respectively, after storage under the room temperature （19℃ -21℃）. The appearances of TPNs were observed under naked eyes. Results： No significant changes of pH value （changes〈 0. 06） and the appearances were noted for the 5 groups of solutions within 24h; The average numbers of microparticles （diameter ≥5μm） from all time points within 24 hours in group 5 were higher than in each group from group 1 to 4 （P〈 0. 01）. Conclusion.. The common usage of glucose and valence 1 electrolytes have little influence on the stability of the TPN solutions, while valence 2 electrolytes have significant effect. Care should be taken to the usage of the valence 2 electrolytes on the preparation of the solution.

关 键 词：全肠外营养液 葡萄糖 电解质 稳定性 

分 类 号：R943[医药卫生—药剂学]