环肽合成的试验研究  

Experimental Study on the Synthesis of Cyclopeptide

作　　者：张莉[1] 李竞成[2] 李聚源[1] 高利华[1] 

机构地区：[1]西安石油大学化学化工学院,陕西西安710065 [2]万向集团汽车研究中心,浙江杭州310023

出　　处：《大连民族学院学报》2006年第3期47-49,共3页Journal of Dalian Nationalities University

摘　　要：采用Fmoc固相合成法得到直链肽,通过空气氧化两个半胱氨酸的巯基生成二硫键,得到一类新型含二硫键的环肽.该环肽经ESI-MS鉴定,RP-HPLC纯化、分析后确定.A novel disulfide bond - bearing eyelopeptides has been designed and synthesized by means of air oxidation of his （ S - Acm） which was synthesized through Fmoc solid-phase synthesis. The reaction products were separated and identified by RP- HPLC and MS spectra.

关 键 词：环肽 固相化学合成 二硫键 环化 

分 类 号：O629[理学—有机化学]