包膜超声造影微泡次谐波特性的优化设计与实验研究  

Optimal design and experiment measurement of the subharmonic characterizations of encapsulated microbubble

作　　者：宗瑜瑾[1] 万明习[1] 王素品[1] 陈红[1] 章国路[1] 

机构地区：[1]西安交通大学生物医学工程系,西安710049

出　　处：《声学学报》2006年第3期233-239,共7页Acta Acustica

基　　金：国家自然科学基金(30270404);国家863计划(2004AA218022)资助项目

摘　　要：基于包膜超声造影微泡在超声场中的理论振动模型,对其次谐波特性进行优化设计,从理论上计算和分析了微泡粒径、膜弹性及声压等对微泡次谐波响应的影响,以期获得其用于非破坏性次谐波成像的最佳条件。另外通过改变膜材料的配比, 制备了具有不同膜弹性的超声造影微泡,对其声学特性进行了体外声学实验测定。仿真计算和实验结果表明,在合适的膜材料配比条件下,制得的平均粒径为3μm左右的包膜微泡,可获得满意的次谐波响应,并且其用于非破坏性次谐波成像时的最佳工作声压约200-400 kPa。Based on the theoretical motion equation of encapsulated microbubbles in the ultrasound field, the subharmonic characterizations of microbubbles were optimally designed and analyzed by a computer aided design system. The effects of size, shell elasticity and acoustic pressure on the subharmonic response of microbubbles were calculated theoretically to obtain the better parameters for nondestructive subharmonic imaging. In addition, the microbubbles with different shell elasticity were prepared, and their subharmonic responses were measured in vitro. The results of theoretical calculation and acoustic measurement showed that good subharmonic enhancement can be obtained by using the encapsulated microbubbles with the mean size of 3 μm, which were prepared from the surfactant solution with the proper ratio of shell material. It is also shown that the best operating acoustic pressure is 200～400 kPa for nondestructive subharmonic imaging based on such kind of microbubbles.

关 键 词：实验测定 优化设计 谐波特性 超声场 微泡 包膜 造影 谐波响应 非破坏性 声学特性 

分 类 号：TH776[机械工程—仪器科学与技术]