学龄儿童动脉顺应性的年龄性别分布及相关因素  

Characteristics and Influencing Factors of Arterial Compliance in Children and Adolescents

作　　者：张力[1] 米杰[1] 程红[1] 赵小元[1] 候冬青[1] 单晓益[1] 

机构地区：[1]首都儿科研究所流行病学研究室,北京市100020

出　　处：《中国循环杂志》2006年第2期121-124,共4页Chinese Circulation Journal

基　　金：北京市科技计划重点项目(H030930030130;H030930030230);国家自然科学基金(30371238)

摘　　要：目的:探讨学龄儿童自然人群动脉顺应性(AC)的基本特点和相关影响因素。方法:采取分层整群抽样方法,在北京一所全日制学校每年级随机抽取一个班,通过问卷排除患心血管疾病个体后, 对其余学生进行体量、血压、青春发育情况检测。采用Pulsetrace指端脉搏波测量仪测定动脉硬化指数(SI),并以此判断被测者AC的情况(AC与SI呈反比),每人重复测量3次,取平均值进行分析。共检测6-17岁儿童288名(男161名, 女127名,平均年龄11．16±2．92岁)。结果:男女生的SI没有差异。SI呈现出随年龄增加而下降的趋势(即AC随年龄增加而升高)。10岁之前AC的上升速度显著高于10岁之后;而青春期发育启动前AC的上升速度也明显高于青春期发育成熟后。多元回归分析的结果显示,年龄、收缩压和体重指数与SI的偏回归系数具有统计学意义。结论:随着年龄的增长,学龄儿童的AC逐渐上升。建议结合年龄和青春发育水平来建立儿童期AC的参照值。Objective：To study the arterial compliance （AC） in children and adolescents and the age-related changes in pulsatile components of arterial system in the early life. Methods ：Two hundred and eighty-eight children （161 boys and 127 girls） aged 6-17 were selected. Arterial compliance, evaluated by the stiffness index （SI） ,was measured with digital pulse wave analyzing method using Pulsetrace machine. Results：There was no difference of SI value between boys and girls. AC value was increased significantly with age, and the increasing velocity was faster in the first several years of life. Multiple linear regression showed that SBP was positively correlated with SI value hut BMI and age were negatively correlated with SI value （ both P 〈 0. 05）. Conclusion：The arterial compliance increases with age in children and adolescents. BMI,SBP and age are main influencing factors of arterial compliance. An age-specific AC reference value should be determined for Chinese children and adolescents.

关 键 词：儿童 青少年 动脉顺应性 

分 类 号：R54[医药卫生—心血管疾病]