MCP-1和VEGF在膀胱癌中表达的相关性及其意义  

Relativity and significance of MCP-1 and VEGF expression in carcinoma of bladder

作　　者：胡毅[1] 关桂梅[2] 孔祥波[1] 董震[2] 

机构地区：[1]吉林大学中日联谊医院泌尿科,吉林长春130033 [2]吉林大学中日联谊医院耳鼻咽喉头颈外科,吉林长春130033

出　　处：《中国实验诊断学》2006年第5期490-492,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的明确单核细胞趋化蛋白1(MCP-1)和血管内皮生长因子(VEGF)在膀胱癌组织中的表达的相关性,初步探讨炎症与膀胱癌发生的关系。方法应用免疫组织化学的方法检测MCP-1和VEGF蛋白在膀胱癌中的表达。结果MCP-1,VEGF在膀胱癌组织中表达均明显高于正常黏膜组织(P<0.01),膀胱癌中二者的表达呈明显的正相关。结论推测慢性炎症下MCP-1激活单核巨噬细胞系统,诱导VEGF表达,与膀胱癌的发生密切相关。Objective To identify the dependability of monocyte chemoattractant protein （MCP-1）and vascular endothelial growth factor （VEGF） in the expression of carcinoma of bladder and approach the relation between inflammation and carcinoma of bladder.Methods Immunohistochemistry investigate the expression of MCP-1 and VEGF. Results Both MCP-1 and VEGF have higher expression in carcinoma of bladder than in normal bladder tissue （ P 〈 0.01 ）, furthermore, three is a positive correlation between MCP-1 and VEGF. Conclusion That MCP-1 activate mononuclear phagocytic system under chronic inflammation, which induce VEGF expression have a close correlation with the carcinogenesis of bladder.

关 键 词：膀胱癌 炎症 单核细胞趋化蛋白-1 血管内皮生长因子 

分 类 号：R737.14[医药卫生—肿瘤]