吸烟与老年性痴呆关系的研究  

Study of cigarette smoking and risk of dementia

作　　者：邓娟[1] 周华东[1] 李敬诚[1] 王延江[1] 张猛[1] 高长越[1] 陈曼娥[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所神经内科,重庆400042

出　　处：《重庆医学》2006年第10期921-923,共3页Chongqing medicine

摘　　要：目的 通过前瞻性研究探讨吸烟和老年性痴呆的关系。方法 以重庆市2820名≥60岁老年人进行2年随访研究，用简易智能量表（MMSE）和美国精神障碍诊断与统计手册第3版修订本（DSM-Ⅲ-R）进行痴呆诊断，受试者分为不吸烟、过去吸烟、现在吸烟，随访时间内记录痴呆发生的例数，采用比例风险回归方法对吸烟和痴呆的关系进行分析。结果 共有121例痴呆患者，84例（69％）为AD，16例（13％）为VD，21例（17％）为其他痴呆．在调整了年龄、性别、教育、血压、饮酒等危险因素后，现在吸烟与不吸烟相比，患AD（RR=2．72；95％CI=1．63～5．42）和VD（RR=1．98；95％CI=1．53～3．12）的危险较大，与轻度吸烟比，重度吸烟引起AD的危险度最大（RR=3．03；95％CI=1．25～4．02），中度吸烟次之（RR=2．56；95％CI=1．65～5．52）。结论 吸烟是老年性痴呆的危险因素，吸烟的状态和数量与痴呆均有关。Objective To investigate the relationship between cigarette smoking and dementia in elderly people through prospective studies. Methods A two-year follow-up study of elderly people was performed. Two thousands eight hundreds and twenty participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagnosed with Mini- Mental State Examination（MMSE） and Diagnostic and Statistical Manual of Mental Disorders（DSM-Ⅲ-R）. Participants were classified as never smokers, past smokers, and current smokers. During follow-up,incident cases of dementia were recorded. The association of smoking and dementia was investigated using proportional hazards regression analysis. Results One hundred and twentyone incident cases of dementia were detected, of which 84 （69%） were Alzhcimer＇s disease, 16 （13 % ） were vascular dementia and 21（17%） were other dementia. Compared with never smokers, current smokers had an increased risk of Alzheimer＇s disease （RR2. 72; 95%CI=1.63 -5.42） and vascular dementia （RRI. 98; 95%CI=1.53-3.12） adjusting for age, sex, education, blood pressure and alcohol intake. Compared with light smokers, the adjusted risk of Alzheimer＇s disease was significantly increased among smokers with a medium level of exposure （RR2.56;95%CI= 1.65-5.52）, with an even higher risk of Alzheimer＇s disease in the heavy smoking group （RR3.03;95 %0 CI = 1.25- 4.02）. Conclusion Smoking is associated with the risk of dementia. This study suggests that both smoking status and amount are associated with dementia.

关 键 词：吸烟 痴呆 危险因素 

分 类 号：R749.161[医药卫生—神经病学与精神病学]