晚期癌性贫血患者血清促红细胞生成素的检测及临床意义  

Detection and clinical analyse of erythropoitin in patients with advanced cancer-related anemia

作　　者：秦瑞[1] 吴达荣[1] 胡俊[1] 毕向军 

机构地区：[1]惠州市中心人民医院,广东惠州516001 [2]广州陆军总医院,广东广州510010

出　　处：《临床和实验医学杂志》2006年第2期107-108,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的研究对晚期癌性贫血患者血清促红细胞生成素(EPO)的水平及其对患者贫血症状作用的临床意义。方法收集多种晚期癌性贫血患者血清,应用放射免疫法检测EPO水平。以正常人、非癌性贫血患者作为对照。同时检测各组血红蛋白、网织红细胞数。分析各组EPO水平差异及其与血红蛋白、网织红细胞数的相关性。结果晚期癌性贫血组患者血清EPO为2.69±1.30μg/L,网织红细胞2.78±1.06%;正常对照组患者血清EPO为1.59±0.69μg/L,网织红细胞1.17±0.35%;非癌性贫血组患者血清EPO为2.78±1.53μg/L,网织红细胞5.46±2.12%;癌性贫血组患者与正常对照组患者比较,其血清EPO、血红蛋白、网织红细胞值均存在显著差异(P<0.01);癌性贫血组患者与非癌性贫血组患者比较,网织红细胞检测结果存在显著差异(P<0.01);癌性贫血组和非癌性贫血组患者EPO和网织红细胞值的相关系数存在显著差异(P<0.01)。结论晚期癌性贫血患者血清EPO水平反应性增高,但机体对EPO反应性减弱。Objective To detect erythropoitin in patients with advanced cancer - related anemia and analyse the clinical signification. Methods Collect the blood of patients with advanced cancer- related anemia and erythropoitin was detected by radioimmuno -assay, hemoglobin and reticulocyte were detected also. Normal and patients with nan - cancer - related anemia were employed as control groups. Results The erythropoitin of patients with advanced cancer - related anemia was 2.69 ± 1.30 ug/L, hemoglobin 89.8 ± 10.0 g/L, reticulocyte 2.78 ± 1.06%. Erythropoitin was 1.59 ±0.69 ug/L, hemoglobin 136. 1 ± 11.3 g/L, retieuloeyte 1.17 ±0.35% in normal controls. Erythropoitin was 2.82 ± 1.16 ug/ L, hemoglobin 90.2 ± 11.5 g/L, retieulocyte 5.7 ± 2. 7% in controls of non - cancer - related anemia. Compared with normal controls, The erythropoitin, hemoglobin and reticulocyte of patients with advanced cancer - related anemia were significant difference（ P 〈 0.01 ）. The reticulocyte was significant different compared the patients with advanced cancer - related anemia with the patients with non - cancer - related anemia （ P 〈0.01 ）. The coefficient of correlation between erythropoitin and retieulocyte was significant different in the patients with advanced cancer - related anemia compared with the patients with non - cancer - related anemia （ P 〈 0.01 ）. Conclusion The erythropoitin of patients with advanced cancer - related anemia was responsively increased but the reactivity of erythropoitin was weakened.

关 键 词：促红细胞生成素 贫血 肿瘤 

分 类 号：R730.43[医药卫生—肿瘤]