早期慢性重症乙型肝炎和乙肝后肝硬化凝血酶原活动度改变的意义  

The significance of variation of prosthrombin activity in early severe chronic hepatitis B and hepatitis B cirrhosis.

作　　者：林春暖[1] 林小荣[1] 邱杰文[1] 

机构地区：[1]汕头大学医学院第二附属医院感染科,广东汕头515041

出　　处：《临床和实验医学杂志》2006年第5期478-479,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的初步评价凝血酶原活动度及胆碱酯酶在早期慢性重症乙型肝炎及乙肝后肝硬化中的意义。方法对近几年我科部分住院乙型肝炎病人凝血酶原活动度、胆碱酯酶及胆固醇做一回顾性分析。结果凝血酶原活动度及胆碱酯酶在早期慢性重症肝炎及肝硬化均有明显改变(P<0.01),是早期诊断重症肝炎的良好指标;早期诊治的重症肝炎与中晚期诊治的重症肝炎,死亡率差异有显著性(P<0.05)。结论凝血酶原活动度联合胆碱酯酶是慢性重症乙型肝炎早诊的良好指标,监测凝血酶原活动度及胆碱酯酶,及早诊治慢性重症乙型肝炎,是提高重症肝炎存活率的关键。Objective To assess preliminarily the significance of prosthrombin activity and cholinesterase in patients with early severe chronic hepatitis B and hepatitis B cirrhosis. Methods We retrospectively analysed the prosthrombin activity, cholinesterase and cholesterol levels of some patients admitted in our hospital in recent years. Results there were significant changes in prosthrombin activity and eholinesterase levels in the early severe chronic hepatitis and hepatic B cirrhosis（ P 〈0.01 ）, therefore they were good indicators of the presence of early severe hepatitis. The morality of patients with severe chronic hepatitis when diagnosed in the early stage were significqnt lower than those diagnosed in the letter stages（ P 〈0.01 ）. Conclusion Prosthrombin Activity combined with cholinesterase levels is a sensitive indicator for diagnosing early chronic severe hepatitis. Early diagnosis and treatment of severe chronic hepatitis by means of monitoring prosthrombin activity and cholinesterase levels is the key to reducing the mortality of these patients.

关 键 词：慢性重症乙型肝炎 乙肝后肝硬化 凝血酶原活动度 胆碱酯酶 

分 类 号：R575.2[医药卫生—消化系统]