左旋布比卡因、罗哌卡因混合芬太尼用于乳癌术后自控镇痛的比较  

Comparison of levobupivacaine or ropivacaine combined with fentenyl for patient-controlled epidural analgesia after radical resection of breast carcinoma

作　　者：付琦[1] 韩雪萍[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《现代医药卫生》2006年第11期1610-1612,共3页Journal of Modern Medicine & Health

摘　　要：目的:比较单用左旋布比卡因,左旋布比卡因和罗哌卡因分别复合芬太尼用于乳癌术后硬膜外自控镇痛的临床效果。方法:选择45例择期行乳癌根治术患者,连续硬膜外麻醉,术后随机分为3组,Ⅰ组:0.125%左旋布比卡因;Ⅱ组:0.125%左旋布比卡因混合芬太尼(2μg/ml);Ⅲ组:0.125%罗哌卡因混合芬太尼(2μg/ml)。观察患者术后24小时内的镇痛效果及不良反应发生率。结果:Ⅰ组VAS评分,总用药量及PCEA泵按压次数与实际进药次数比值显著高于其他两组(P<0.05),3组不良反应发生率无明显差异(P>0.05)。结论:0.125%左旋布比卡因复合芬太尼(2μg/ml)用于乳癌术后镇痛,效果满意,无明显不良反应。Objective：To compare the clinical effect of levobupivacaine alone and levobupivacaime or ropivacaine combined with fentanyl for patient -controlled epidural analgesia （PCEA） after radical resection of breast carcinoma. Methods：45 patients after radical resection of breast carcinoma under continous epidural anesthesia were randomly divided into three groups. Group Ⅰ received 0.125% levobupivacaine, group Ⅱ 0.125% levobupivacaine plus fentanyl （2 μg/ml）,group Ⅲ 0.125% repivacaine plus fentanyl （2 μg/ml）. Analgesia effect and incidence of side-effect were observed for up to 24 hours after operation. Results：The VAS score ,total drug dosage, D1/D2 ratio in group I were signifieandy higher than those in other groups （P〈0.05）.The difference in incidence of side-effect among three groups was not significant （P〉0.05）.Conclusion：PCEA with 0.125% , levobupivaeaine containing fentanyl （2 μg/ml） provides adequate pain relief and fewer side-effect after radical resection of breast ocarcinoma.

关 键 词：左旋布比卡因 罗哌卡因 芬太尼 自控镇痛 

分 类 号：R73[医药卫生—肿瘤]