胰岛素样生长因子-I受体在人皮肤血管瘤不同分期的表达  

The expression of IGF-IR in different stages of human dermal hemangiomas

作　　者：张平[1] 许成蓉[1] 毕昊[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院皮肤科,430030 [2]华中科技大学同济医学院生化与分子生物学系,430030

出　　处：《中国麻风皮肤病杂志》2006年第5期363-365,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:探讨胰岛素样生长因子-I受体与血管瘤发生发展的关系。方法:采用免疫组化SP法和半定量RT-PCR检测不同分期血管瘤中IGF-IR的表达水平,并与血管畸形及正常皮肤进行比较。结果:SP法和半定量RT-PCR结果均显示增殖期血管瘤内皮细胞IGF-IR表达水平增高,与血管畸形及正常皮肤组织间差异显著;而消退期的IGF-IR表达水平降低与血管畸形及正常皮肤相比,差异无显著性。结论:IGF-IR与血管瘤的发生发展有密切关系,为寻找皮肤血管瘤的诊断与治疗的新靶点提供了新的思路。Objective： To study the relationship between insulin - like grouth factor-Ⅰ receptor （IGF- IR） and the progress of hemangioma, Methods： The expression of IGF - IR in the different stages of hemangiomas was measured using SP method and RT - PCR, compared with vascular malformation and normal skin tissues. Results： The results of both SP method and RT- PCR showed that the expression of IGF- IR in the proliferative stage of hemangioma was much higher than that in vascular malformation and normal skin tissues. The expression of IGF - IR in the resolving stage of hemangioma was decreased to a similar level to vascular malformation and normal skin tissues. Conclusion： There is significantly positive correlation between the expression of IGF- IR and proliferative degree of hemangioma, which may provide a new train of thought for finding the target to diagnose and treat hemangiomas.

关 键 词：胰岛素样生长因子-Ⅰ受体 血管瘤 皮肤 表达 

分 类 号：R739.5[医药卫生—肿瘤]