COX-2和c-erbB-2在乳腺癌中的表达及其相互关系  

Expression of cyclooxygenase-2 and c-erbB-2 in human breast cancer and their correlationship

作　　者：李莉[1] 施俊义[1] 方国恩[1] 盛援[1] 

机构地区：[1]第二军医大学长海医院普通外科,上海200433

出　　处：《第二军医大学学报》2006年第5期503-506,共4页Academic Journal of Second Military Medical University

摘　　要：目的:研究乳腺癌中环氧化酶2(COX-2)和c-erbB-2的表达及其相互关系。方法:采用免疫组织化学法检测48例乳腺癌组织中COX-2与c-erbB-2的表达情况,分析其相互关系及与乳腺癌临床病理学特征间的联系。结果:乳腺癌中COX-2表达阳性率达60.4%(29/48),肿块>2 cm、淋巴结转移阳性、雌激素受体(ER)阴性、孕激素受体(PR)阴性者COX-2表达明显高于肿块<2 cm、淋巴结转移阴性、ER阳性、PR阳性者,而COX-2表达与患者年龄、肿瘤病理类型及肿瘤分期无关。c-erbB-2的表达阳性率为39.6%(19/48),淋巴结转移阳性及激素受体阴性者c-erbB-2表达明显高于淋巴结转移阴性及激素受体阳性者,而与年龄、肿块大小、病理学类型无关。在c-erbB-2阳性的乳腺癌患者中,COX-2表达阳性率为84.2%(16/19),而c-erbB-2阴性的乳腺癌患者中,COX-2阳性表达率为44.8%(13/29),两者相比差异显著(P=0.006)。结论:COX-2在乳腺癌中高水平表达且与c-erbB-2表达有关,提示乳腺癌中COX-2与c-erbB-2存在互相调控机制,共同促进肿瘤的发生和发展。Objective：To investigate the expression and correlation of cyclooxygenase-2 （COX-2） and c-erbB-2 in human breast cancer. Methods： The expressions of COX-2 and c-erbB-2 in 48 breast cancer patients with breast cancer were detected with immunohistochemistry examination and was analyzed. The relationship between their expression and the clinicopathologic characters of breast cancer was also analyzed. Results： The positive rate of COX-2 was 60.4% （29/48） in these patients; the expression was higher in patients with tumor size larger than 2 cm, lymph node metastasis, and negative expression of ER or PR, but was not related with the ages, the pathologic types and the TNM stages. Expression of c-erbB-2 was identified in 39.6% （19/48） of these patients; the expression was significantly higher in patients with lymph node metastasis or negative expression of ER and PR, but was not related width the ages, the sizes and the pathologic types. COX-2 was positive in 84.2% （16/19） of patients positive of c-erbB-2 and in 44. 8 % （13/29） of patients negative of c-erbB-2, with significant difference found between the 2 figures（P=0. 006）. Conclusion： The high expression of COX-2 in breast cancer is related to the expression of c- erbB-2, suggesting that they may regulate each other and jointly contribute to the tumorigenesis and progression of breast cancer.

关 键 词：乳腺肿瘤 环氧化酶2 C-ERBB-2 

分 类 号：R737.9[医药卫生—肿瘤]