年龄相关性白内障患者晶状体上皮细胞的死亡方式及超微结构改变  

Death ways and ultrastructure changes of lens epithelial cell in patients with senile cataract

作　　者：郑广瑛[1] 刘玥[1] 张楠[2] 

机构地区：[1]郑州大学第一附属医院眼科,郑州450052 [2]郑州市第五人民医院眼科,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第3期497-499,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省教育科技攻关基金资助项目

摘　　要：目的:探讨年龄相关性白内障晶状体上皮细胞(lensepithelialcell,LEC)的死亡方式和细胞超微结构改变。方法:取年龄相关性白内障患者晶状体前囊共12例,其中6例皮质性白内障,6例核性白内障。分别行透射电镜观察。结果:LEC形状扁平,正常细胞和变性坏死细胞间隔存在,线粒体广泛空泡化。所有标本均发现胀亡细胞,3例核性白内障及4例皮质性白内障标本发现典型paraptosis样细胞,仅有1例核性白内障标本发现早期凋亡细胞,细胞内偶见髓样体存在。结论:线粒体空泡化可能在年龄相关性白内障LEC的发生发展中起重要作用,胀亡和paraptosis可能是LEC的主要死亡方式。Aim： To evaluate the death ways and uhrastructure changes of lens epithelial cell in the senile cataract. Methods ：Twelve cases of anterior capsules were observed under transmission electron microscope. Results： The epithelial cell turned to fiat, extensive vesivulation was observed in mitochondrikon, the gap between cells was enlarged.Oncosis cells were found in all samples, three nuclear cataract and four cortical cataract had paraptosis cells, hut only one sample had apoptosis cell. Conclusion： Vesivulation of mitochondrion contributes to the development of senile cataract, and oncosis and paraptosis may he the main death ways of LEC.

关 键 词：白内障 晶状体上皮细胞 线粒体 凋亡 胀亡 paraptosis 

分 类 号：R776.1[医药卫生—眼科]