人乳癌组织中血管生成素-2及其受体Tie-2的表达  

Expression of angiopoietin-2 and Tie-2 in human breast cancer tissue

作　　者：高冬玲[1] 郭克民[2] 张岚[1] 张红新[1] 张云汉[1] 

机构地区：[1]郑州大学第一附属医院病理科河南省肿瘤病理重点实验室,郑州450052 [2]郑州大学基础医学院法医学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第3期517-519,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨乳癌组织中血管生成素-2(Ang-2)、血管生成素2受体Tie-2的表达。方法:应用免疫组化SP法检测28例人乳腺导管内癌、49例浸润性导管癌、25例乳腺纤维腺瘤和51例正常乳腺间质组织中Ang2及Tie-2、CD34的表达,根据CD34的表达情况计算微血管密度(MVD)。结果:正常乳腺间质组织中Ang-2、Tie-2阳性表达率分别为12.0%(6/50)和18.0%(9/50),在乳腺纤维腺瘤组织中的阳性表达率为16.0%(4/25)和20.0%(5/25);而在乳腺导管内癌组织中的阳性表达率分别为53.57%(15/28)和64.28%(18/28),在乳腺浸润性导管癌组织中的表达率分别为93.87%(46/49)和97.96%(48/49),均显著高于正常乳腺间质组织和乳腺纤维腺瘤组织中的表达(P<0.01)。乳癌组织CD34的表达显著高于其在正常乳腺间质组织中的表达。结论:Ang2及Tie2的表达与乳癌血管生成关系密切,Ang2表达与乳癌的浸润有关。Aim ： To explore the expression and significance of Angiopoietin-2 and Tie-2 in breast cancer tissue. Methods：The expressions of Ang-2, Tie-2, CD34 were detected by immunohistochemistry SP method in 28 cases of intraductal carcinoma in situ, 49 cases of invasive ductal carcinoma, 25 cases of fibroadenoma of breast, and 50 cases of normal mammary tissue. The microvessel density （MVD） of the normal and tumor tissue based on the expression of CD34 was calculated and analyzed the relation between the pathological character of mammary cancer. Results： The positive rate of Ang-2 and Tie-2 in the normal mammary stroma, fibroadenoma of breast, intraductal carcinoma in situ and invasive duetal carcinoma were 12.0% and 18.0% , 16.0% and 20.0% , 53.57% and 64.28% , 93.87% and 97.96% , respectively. The expression levels of Ang-2 and Tie-2 in carcinoma tissue were significantly higher than those in normal tissue and fibroadenoma of breast （ P 〈0.01 ）. The expression level of CD34 in carcinoma tissue was significantly higher than that in normal tissue. Conclusion ： The expressions of Ang-2 and Tie-2 have intimate correlation with the sprouting new vessel of mammary cancer. The expression of Ang-2 is connected with the nature of breast tumor and the metastasis of breast cancer.

关 键 词：乳腺肿瘤 血管生成素-2 血管生成素-2受体 微血管密度 

分 类 号：R737.902[医药卫生—肿瘤]