乳癌组织中MMP-2、TIMP-2的表达  

Expression of MMP-2 and TIMP-2 in breast carcinoma tissue

作　　者：申培红[1] 李珊珊[2] 卢金镶[1] 张云汉[2] 

机构地区：[1]郑州市中心医院病理科,郑州450007 [2]郑州大学基础医学院病理学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第3期552-553,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨MMP-2和TIMP-2与乳癌浸润转移的关系。方法:采用免疫组化法分析乳腺导管内原位癌(24例)及乳腺浸润性导管癌(58例)组织中MMP2和TIMP2的表达情况。结果:乳腺导管内原位癌及浸润性导管癌组织中MMP-2的阳性表达率分别为54.17%(13/24)、44.82%(26/58),2组比较差异无统计学意义(P>0.05);乳腺导管内原位癌TIMP2的阳性率为91.67%(22/24),高于浸润性导管癌组织中的51.72%(30/58)(P<0.05)。结论:乳癌组织中TIMP2的表达状况与乳癌的浸润和转移有关。Aim ： To explore the relationship between the expression of MMP-2, TIMP-2 and invasion and metastasis of breat carcinoma. Methods：Immunohistochemistry technique SP method was used to detect the expression of MMP-2 and TIMP-2 in 24 cases of breast ductal carcinoma in situ and 58 cases of invasive ductual carcinoma tissue. Results： In the ductal carcinoma in situ and the invasive ductual carcinoma tissue,the positive rate of MMP-2 was 54. 17% （13/24） and 44.82% （26/58） , respectively, and there was no significant difference （ P 〉 0.05 ） ; that of TIMP-2 were 91.67% （ 22/ 24） and 51.72% （30/58） , respectively, and there was significant difference （P 〈 0.05 ）. Conclusion ：The expression of TIMP-2 is related to the invasion and metastasis of breast carcinoma.

关 键 词：乳腺肿瘤 癌 MMP-2 TIMP-2 

分 类 号：R737.9[医药卫生—肿瘤]