术前化疗对54例晚期神经母细胞瘤患者手术切除率的影响  

The Effect of Preoperative Chemotherapy on Resection Rate of 54 Cases with Advanced Neuroblastoma

作　　者：王智辉[1] 孙晓非[1] 甄子俊[1] 刘冬耕[1] 林桐榆[1] 夏奕[1] 凌家瑜[1] 

机构地区：[1]中山大学肿瘤防治中心内科,在读研究生广州市510060

出　　处：《中国肿瘤临床》2006年第10期580-582,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨术前化疗对晚期神经母细胞瘤(neuroblastoma,NB)手术切除率的影响。方法:回顾性分析1999年1月至2004年12月收治的54例行术前化疗的Ⅲ、Ⅳ期NB患儿,其中Ⅲ期20例,Ⅳ期34例。54例中行CAV与EP方案交替化疗40例,行CYVADIC或MAID方案化疗14例。结果:54例化疗总计318疗程,平均5.9疗程。化疗有效率83.3%,手术切除率74.1%(40/54),Ⅲ期85.0%(17/20),Ⅳ期67.7%(23/34),手术完整切除率40.0%(16/40)。1年、2年生存率分别为74.1%和42.6%,主要化疗不良反应为骨髓抑制。结论:术前化疗能提高晚期NB可手术切除率及延长生存期。Objective： To investigate the effect of preoperative chemotherapy on resection rate of advanced NB. Methods： The data of 54 cases with advanced NB of stage Ⅲ and Ⅳ receiving preoperative chemotherapy, from Jan. 1999 to Dec. 2004, were retrospectively analyzed. Among the patients, 20 were of stage Ⅲ, 34 were stage Ⅳ. Forty patients received alternative chemotherapy with the regimen of CAV and EP and other 14 with the regimen of CYVADIC or of MAID. Results： The number of total courses was 318 and the average was 5.9 in the 54 cases. The effective rate of chemotherapy was 83.3%. The resection rate was 74.1% （40/54）, The cases of stage Ⅲ and of Stage IV amounted to 85.0% （17/20） and 67.7% （23/34）, respectively. The complete resection rate was 40.0% （16/40） and the 1-year and 2-year survival rate was 74.1% and 42.6%, respectively. The major side effect was myelosuppression. Conclusion： The preoperative chemotherapy can improve the resection rate of advanced NB and can prolong the overall survival.

关 键 词：神经母细胞瘤 术前化疗 手术切除率 晚期 

分 类 号：R730.5[医药卫生—肿瘤]