大鼠尾壳核-海马癫痫电网络的神经信息编码特征  

CHARACTERISTICS OF NEURAL INFORMATION ENCODING IN EPILEPTIC NETWORKS INVOLVED IN RAT CAUDATE PUTAMEN-HIPPOCAMPI

作　　者：甘丽[1] 刘青[1] 刘慧浪[1] 刁芳明[1] 邹祖玉 韩丹[1] 

机构地区：[1]武汉大学医学院生理学系 [2]病理学与病理生理学系,湖北武汉430071

出　　处：《中国应用生理学杂志》2006年第2期179-184,共6页Chinese Journal of Applied Physiology

基　　金：湖北省自然科学基金资助项目(2003ABA123)

摘　　要：目的：观察强直电刺激大鼠右侧尾壳核（CPu）时，CPu-海马（HPC）网络癫痫的神经信息编码特征。方法：雄性SD大鼠59只。急性或慢性强直电刺激CPu（acute tetanization of the right CPu or chronic tetanization of the right CPu，ATRC or CTRC）（60Hz．0．4～0．6mA，2s）诱导大鼠癫痫模型。结果：①ATRC可以诱导双侧HPC神经元出现非对称性癫痫相关性单位电活动．增加对侧HPC单位放电时间间隔（Interspike interval，ISI）点分布的分岔角度。②CTRC可以诱导双侧CPu网络出现尖波样连续发放，同侧振荡样网络发作具有明显的相位移动特征；频率变化顺序为70Hz、110Hz、35Hz以及30Hz．与时间呈显著的负相关；振荡波波峰间隔（Interpeak interval，IPI）和波峰振幅逐渐增大，与时间呈显著正相关。③CTRC后加ATRC可以分别诱导双侧CPu网络出现原发性后放电。结论：激活CPu可以跨大脑半球重建双侧CPu—HPC癫痫电网络．其神经信息编码特征可能成为癫痫发生的神经信息学基础。Aim： To study the characteristics of neural information encoding of the epileptic networks involved caudate-putamen（CPu） and the hippocampi induced by tetanization of the right CPu in rats. Methods： Experiments were performed on 59 SD rats. Acute or chronic tetanization of the right CPu（ATRC or CTRC）（60Hz ,0.4～0.6 mA, 2 s） was used to induce rat epilepsy. Results： ①The bursting or primary unit afterdischarges of single neurons were asymmetric in dual hippocampi induced by the ATRC. ②Continuous sharp waves were observed in ipsilateral or contralateral CPu induced by the CTRC. The oscillatory network seizures with phase shift appeared between two sharp waves in ipsilateral CPu. The frequency of oscillatory waves was negatively correlated with the time and fluctuated from 70 Hz to 110 Hz, then to 35 Hz, and finally to 30 Hz. ③In the contralateral side primary network afterdischarges in the CPu were induced by the CTRC. Therefore, the characteristic primary network afterdischarges could be shifted from the CPu or to the HPC, but amplified. On the other hand, HPC sharp waves could be depressed when the CPu network seizures occurred. Conclusion： The reestablishment of CPu-hippocampal epileptic networks could be transhemispherically promoted by over-activation of the right CPu network, in which bilateral hippocampal neuronal network and CPu neural network were involved in some particular pathophysiological information encoding.

关 键 词：尾壳核 海马 癫痫电网络 神经信息编码 强直电刺激 

分 类 号：R742.1[医药卫生—神经病学与精神病学]