骨肉瘤侵袭骺板的影像学与BMP-2表达的研究  

The Research of Imaging Features and Expression of BMP-2 Protein in Osteosarcoma Involved Epiphyseal Plate

作　　者：张薇薇[1] 马强华[2] 杨晓萍[2] 

机构地区：[1]兰州大学临床医学院,甘肃兰州730000 [2]兰州军区兰州总医院MR室

出　　处：《实用放射学杂志》2006年第5期563-566,共4页Journal of Practical Radiology

摘　　要：目的比较不同影像学检查方法显示骨肉瘤骺板侵袭的阳性率,并从分子生物学水平探讨骨形成蛋白-2(bone morpho-genetic prote in-2,BMP-2)对骨肉瘤侵袭可能的发生机制。方法分析36例经病理证实的骨肉瘤患者的X线片和MR I图像中骺板侵袭征象阳性率并做统计分析;对其标本的不同部位取材并做BMP-2的免疫组织化学染色。结果X线、MR I检查对骨肉瘤侵袭骺板的显示率分别为44.44%、100.00%(P<0.05)。BMP-2在瘤体、骺板浸润区、正常骺板、瘤周正常组织的阳性表达率分别为88.89%、94.44%、10.00%和20.00%(P<40.05)。瘤体、骺板浸润区的表达显著高于正常骺板、瘤周正常组织。结论MR对骨肉瘤骺板侵袭的显示率具有明显的优势。BMP-2与骨肉瘤侵袭骺板具有一定的关系。Objective To discuss the relationship between BMP -2 protein and possible mechanism and to compare the postive rate of two different imaging examinations in evaluating the epiphyseal plate involved by osteosarcoma. Methods Radiographic and MRI features of cpiphyseal plate extension by osteosarcoma confirmed by pathology in 36 cases were analysed retrospectively. The expression of BMP - 2 was detected with immunohistochemical SABC method in different part of specimen. Results The diagnostic accurate rate in evaluating the epiphyaeal plate extension from osteosarcoma by X - ray and MRI was 44.44% and 100% respectively. The positive reactive rate of BMP - 2 in tumor body, epiphyseal plate soak distrlct, normal epiphyseal plate and normal tissue nearby the tumor was 88.89% （32/36） ,99.44% （34/36） , 10.00% （1/10） and 20.00% （2/10） respectively. Conclusion MRI is more sensitive to radiography in evaluating the cpiphyseal plate involved by osteosarcoma, the higher positive reactive rate of BMP -2 protein is correlated to the epiphyseal plate extension of osteosarcoma.

关 键 词：骨肉瘤 骺板 骨形成蛋白-2 X线摄影术 磁共振成像 

分 类 号：R738.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]