肾癌多层螺旋CT成像与肿瘤血管形成的相关性  

Correlation of multislice spiral CT findings with vascular endothelial growth factor expressions and microvessel density in renal cell carcinoma

作　　者：夏军[1] 骆平[1] 王晖[1] 雷益[1] 刘品霓[1] 徐化剑[1] 陈志刚[1] 

机构地区：[1]深圳市第二人民医院放射科,广东深圳518035

出　　处：《南方医科大学学报》2006年第5期629-631,共3页Journal of Southern Medical University

基　　金：深圳市科技计划资助项目(JH200507120852A)~~

摘　　要：目的探讨肾癌多层螺旋CT扫描征象与肾癌组织微血管密度及癌组织血管内皮生长因子(VEGF)表达之间的相关系。方法对47例肾癌行多层螺旋CT平扫及增强扫描,同时对肿瘤标本及癌旁正常组织采用免疫组织化学染色,检测肿瘤组织的微血管密度及VEGF的表达。结果(1)随着肾癌病理分级升高,VEGF的表达及微血管密度计数明显增高(P<0.05);(2)肾癌组织中,VEGF阳性表达与微血管密度计数显著正相关(P<0.01);(3)肾癌VEGF基因表达,微血管密度计数与肿瘤大小、瘤内坏死、囊变、强化、淋巴结增大、肾静脉或下腔静脉侵犯及远处转移密切相关(P<0.01)。结论(1)肾癌的多层螺旋CT能准确反映肾癌的病理学基础。(2)肾癌的多层螺旋CT表现与VEGF基因表达及肿瘤微血管密度计数存在内在关系,可以据此术前评估其生物学行为与恶性程度并预测肿瘤的转移及侵犯。Objective To study the correlation of multislice spiral CT features and vascular endothelial growth factor （VEGF） expressions and microvessel density （MVD） in renal cell carcinoma （RCC）. Methods Fourth-seven patients with pathologically confirmed RCC were examined by multislice spiral CT, and VEGF expressions and MVD of the RCC and the adjacent normal tissues were determined by immunohistochemistry with specific monoclonal antibodies. Results VEGF expression and MVD in the RCC and adjacent normal tissues increased with the pathological grades ofRCC （P〈0.05）, VEGF expression was found to significantly correlate with MVD （r=0.67, P〈0.01）. The positive expression of VEGF and MVD were associated with the findings by multislice spiral CT scan of tumor size, intratumor necrosis, cystic degeneration, intensity signal, lymph node metastases, invasion of the renal vein or inferior vena cava, and invasion of the adjacent organs or distant metastases （P〈0.01）. Conclusion Multislice spiral CT findings can be indicative of the histopathology of RCC, and some CT findings are closely correlated with MVD and VEGF expressions in RCC, which may help evaluate the biological behavior and malignancy of the tumor and predict tumor invasion and metastasis.

关 键 词：肾细胞癌 体层摄影术 微血管密度 血管内皮生长因子 

分 类 号：R737.11[医药卫生—肿瘤]