幽门螺杆菌血清CagA抗体与消化系统恶性肿瘤的关系  

Relationship between CagA seropositivity of Helicobacter pylori and Gastrointestinal malignant tumor

作　　者：何晋德[1] 刘玉兰[1] 王怀唐[1] 叶辉[1] 张娇[1] 

机构地区：[1]北京大学人民医院消化科,北京100044

出　　处：《中国医师杂志》2006年第5期617-619,共3页Journal of Chinese Physician

摘　　要：目的 探讨幽门螺杆菌（Hp）血清CagA抗体与胃癌和非胃癌消化系统恶性肿瘤的关系。方法 以结直肠癌和肝胆胰癌为非胃癌对照组，检测胃癌患者血清抗-Hp-CagA-IgG和抗-Hp-IgG，并分析它们与胃癌和对照组的关系。结果 胃癌组患者共50例，结直肠癌和肝胆胰癌各35例（非胃癌组70例），它们的年龄（F=0.0l，P〉0.1）和性剐（〈=1．65，P〉0．1）组成具有可比性；CagA抗体（＋）率胃癌（58，0％）比非胃癌组（28．6％）高（x^2=10，46，P〈0．01），OR（优势比）=3．45（95％CI 1．61-7．42）；抗-Hp-IgG（＋）率胃癌（68．0％）比非胃癌组（35．7％）高（x^2=12，16，P〈0．01），OR=3.83（95％CI 1．77-8．23）；结 直肠癌和肝胆胰癌间CagA抗体（＋）率（34．3％vs22．9％，x^2=1.12，P〉0.1）和抗-Hp-IgG（＋）率（34，3％vs37.1％，x^2=0．06，P〉0．1）相当。结论 血清Hp抗体与胃癌关系极为密切，抗-Hp-IgG和CagA抗体对胃癌具有同样的预示性；CagA抗体和抗-Hp-IgG阳性者检出胃癌的危险性分别是非胃癌消化系统恶性肿瘤的3．5倍和3.8倍。Objective To investigate relationship between anti-CagA of helicobacter pylori （H. pylori） and gastric cancer（GC） and non-gastric gastrointestinal malignant tumor （NG-GMT）. Methods The indexes such as anti- H. pylori -CagA-IgG and anti- H. pylori -IgG were measured in 50 GC patients and 70 NG-GMT control patients including 35 cases with colorectal cancer （CRC） and 35 with hepatobilio-pancreatic cancer （HBPC）. Results The age and sex configuration of the patients involved in the study had no significant difference （ F =0. 01, P 〉0. 1 and x^2 = 1.65, P 〉0. 1 ）. The positive rates of anti-CagA were 58.0% （29/50） in GC and 28.6% （20/70） in NG- GMT （ x^2 = 10. 46, P 〈0. 01 ）, the odds ratio （OR） of which was 3. 45 [95% confidence interval （CI） 1.61 to 7. 42], The positive rates of anti- H. pylori -IgG were 68. 0% （34/50） in GC and 35.7% （25/70） in NG-GMT （ x^2 = 12. 16, P 〈 0. 01 ）, the OR of which was 3, 83 （95% CI 1. 77 to 8.23）. The positive rates of anti-CagA in CRC and HBPC （34. 3% vs 22. 9% respectively, x^2 = 1, 12, P 〉 0. 1 ） and those of anti-H, pylori-IgG （34. 3% vs 37. 1% respectively,x^2 = 0. 06, P 〉 0. 1 ） were not significantly different. Conclusion The seropositivity of H. pylori, anti-CagA and anti-H, pylori-IgG are associated with the risk of gastric cancer.

关 键 词：消化系统肿瘤 幽门螺杆菌 免疫球蛋白G 抗体 病毒 

分 类 号：R735[医药卫生—肿瘤] R573.1[医药卫生—临床医学]