基质金属蛋白酶2及其组织抑制因子2在子宫内膜癌中的表达及意义  

Expression and significance of matrix metalloproteinase 2 and its tissue inhibitor in human endometrial carcinoma

作　　者：生秀杰[1] 阎进[2] 宋和存[3] 王沂峰 

机构地区：[1]广州市第二人民医院妇产科研究所,510150 [2]沈阳市公安医院妇科 [3]中国医科大学附属第一医院妇科

出　　处：《肿瘤研究与临床》2006年第5期319-321,共3页Cancer Research and Clinic

摘　　要：目的探讨基质金属蛋白酶2(MMP-2)与其组织抑制因子2(TIMP-2)在子宫内膜癌中的表达及意义。方法应用免疫组织化学方法对40例子宫内膜癌,12例子宫内膜不典型增生,12例正常子宫内膜中的MMP-2,TIMP-2的表达进行检测,并分析MMP-2,TIMP-2的表达与子宫内膜癌临床病理特征之间的关系。结果MMP-2和TIMP-2在正常子宫内膜、子宫内膜不典型增生及子宫内膜癌的阳性表达率逐渐升高;在子宫内膜癌组织中,MMP-2/TIMP-2阳性表达面积比值随着病理分化程度的降低、肌层浸润的加深及临床分期的升高而逐渐增高。结论MMP-2与TIMP-2的表达与子宫内膜癌的发生相关,MMP-2/TIMP-2表达的不平衡可能是子宫内膜癌发生发展的因素之一。Objective To study the express of matrix metalloproteinase（MMP）-2 and tissue inhibitor of metalloproteinase（TIMP）-2 protein in human endometrial carcinoma. Methods The Immunohistochemistry was used to measure the MMP-2, TIMP-2 in endometrial carcinoma tissue of 40 patients, the atypical hyperplasia of 12 samples and the normal endometrium of 12 samples. Results The positive express of MMP-2 and TIMP-2 in the normal endometrium, atypical hyperplasia and endometrial carcinoma was increased gradually. In endometrial carcinoma, with progression of clinical stage and decrease of histological grade as well as deepening of cancer invasion, the ratio of MMP-2/TIMP-2 was increased. Conclusions The expression of MMP-2 and TIMP-2 were connected with endometrial carcinoma. The imbalance of MMP-2/TIMP-2 in the endometrial cancer might be one of the pathogenesis and development.

关 键 词：基质金属蛋白酶2 组织抑制因子2 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]