血清AFU与AFP测定对原发性肝癌的诊断价值  

Diagnostic Value of AFU and AFP Determination for Primary Hepatic Carcinoma

作　　者：郑雅娜[1] 左炬[2] 

机构地区：[1]湖南省长沙市妇幼保健院 [2]湖南省肿瘤医院,湖南长沙410078

出　　处：《医学临床研究》2006年第5期719-720,共2页Journal of Clinical Research

摘　　要：【目的】探讨血清-αL-岩藻糖苷酶(AFU)对原发性肝癌(PHC)的诊断意义。【方法】测定450例PHC、114例肝硬化、311例转移性肝癌、58例良性肝占位性病变及200例正常对照者的血清AFU与甲胎蛋白(AFP),并对95例手术后患者随访测定AFU。【结果】PHC血清AFU活性显著高于其他各组。血清AFU和AFP对PHC的诊断敏感性分别为87.2%和80.1%,联合检测敏感性为91.8%。PHC手术切除癌肿后血清AFU活性明显下降,复发时可再度升高。【结论】AFU对PHC的诊断和复发监测有重要价值。[Objective]To study the significance of serum α-L-fucosidase（AFU） and alpha fetoprotein （AFP）in the diagnosis of primary hepatic carcinoma（PHC）. [Methods]The activities of serum AFU and AFP were measured in 450 cases of PHC, 114 cases of liver cirrhosis（LC）, 311 cases of metastatic hepatic carcinoma（MHC）, 58 cases of benign focal lesions（BFL） and 200 healthy subjects. In 95 patients with PHC,followo up detections of serum AFU were carried out after tumor resection. [Results]The AFU activities in patients with PHC were significantly higher than any other groups. The diagnostic sensitivities of serum AFU and AFP in patients with PHC were 87. 2% and 80. 1% respectively, and the combined diagnostic sensitivities of AFU and AFP reached the level of 91.8%. The serum AFU in patients with PHC was significantly reduced after operations. In patients with PHC recurrence, the serum AFU increased significantly again. [Conclusion]The serum AFU is a useful marker for the diagnosis of PHC and monitoring its recurrence.

关 键 词：肝肿瘤/诊断 甲胎蛋白类/血液 岩藻糖甘酶/血液 

分 类 号：R735.7[医药卫生—肿瘤]