人参果皂苷对急性心肌梗塞犬冠状动脉循环及心肌氧代谢的影响  

Effects of ginseng fruit saponins(GFS)on coronary circulation and myocardial oxygen metabolism in dogs with acute myocardial infarction

作　　者：武毅[1] 于晓风[1] 曲绍春[1] 睢大员[1] 陈燕萍[2] 马兴元[2] 

机构地区：[1]吉林大学药学院药理学教研室,吉林长春130021 [2]吉林大学化学院天然药物化学研究室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2006年第3期428-431,共4页Journal of Jilin University：Medicine Edition

基　　金：国家九五科技攻关课题(96-901-05-155)

摘　　要：目的:研究人参果皂苷(ginseng fruit saponins,GFS)对急性心肌梗塞犬冠脉循环及心肌氧代谢的影响。方法:犬结扎左冠状动脉前降支6 h造成急性心肌梗塞模型,同时静脉滴注GFS进行治疗,通过MP-27型电磁流量计记录冠状动脉血流量,以CORNIHG 178型血气分析仪测定动、静脉血氧含量,观察心肌氧代谢变化。结果:与心肌梗塞模型组比较,静脉滴注GFS 5和10 mg.kg-1,可使急性心肌梗塞6 h犬心肌血流量明显增加,冠脉血管阻力明显降低(P<0.05或P<0.01),并能使心肌氧利用率及心肌耗氧量明显降低(P<0.05或P<0.01),对心肌耗氧指数无明显影响(P>0.05)。结论:GFS可通过改善冠脉循环,增加心肌血液供给,同时降低心肌耗氧及降低心肌氧利用率发挥抗急性心肌缺血作用。Objective To study the effects of ginseng fruit saponins （GFS） on the coronary circulation and cardial oxygen metabolism in dogs with acute myocardial infarction. Methods The acute myocardial infarction model was induced by ligating the left anterior descending coronary of dogs for 6 h. 90 rain after treatment with GFS, the blood flow of coronary artery was determined by using electromagnetism flowmeter with MP-27 type. At the same time, the blood oxygen contents of artery and vein were determined by using analysis instrument of blood gas with CORNIHG 178 type. Results After treated by GFS （in a dosage of 5 and 10 mg· kg^-1 iv drip for 90 min）, the myocardial blood flow （MBF） was increased and coronary vascular resistance （CVR） was decreased significantly. Meanwhile the cardiac oxygen consumption and myocardial oxygen utilization rate were also decreased, but cardiac oxygen consumption index had not changed significantly. Conclusion GFS has protective effects on acute myocardial ischemia through improving the coronary circulation, increasing myocardial blood supply and decreasing cardiac oxygen consumption and myocardial oxygen utilization rate.

关 键 词：人参果皂苷 心肌梗塞 冠脉循环 心肌氧代谢 疾病模型 动物 

分 类 号：R-332[医药卫生] R285.5