鲍温样丘疹病组织病理学变化及其与细胞凋亡的关系  

Histopathological changes of bowenoid papulosis and its relationship with apopotosis

作　　者：刘喜福[1] 于艳[1] 付爱华[1] 王晓丽[1] 

机构地区：[1]吉林大学第一医院皮肤科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2006年第3期496-497,F0003,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(20010593)

摘　　要：目的:探讨鲍温样丘疹病的组织病理学变化、生物学行为及其与细胞凋亡的关系。方法:通过HE染色观察鲍温样丘疹病的病理变化;运用TUNEL技术原位观察20例鲍温样丘疹病及5例正常皮肤组织的细胞凋亡情况。结果:鲍温样丘疹病的病理变化主要为表皮增生、细胞极性紊乱,核大而深染,可有角化不良、多核角质形成细胞以及异常核丝分裂相;在鲍温样丘疹病组组织切片中均可见到凋亡细胞,而5例正常对照组皮肤组织中,仅在角质层下偶见个别凋亡细胞。细胞凋亡阳性物质呈棕黄色,位于细胞核内。鲍温样丘疹病组细胞凋亡指数(27.1±15.1)高于对照组(6.8±3.5)(P<0.01)。结论:鲍温样丘疹病的良性生物学行为表现可能与细胞凋亡增多有关。Objective To study the histopathological changes and biological behavior of bowenoid papulosis and its relationship with apopotosis. Methods 20 bowenoid papuloses and 5 normal skin tissues were examined by DNA nick end labeling （TUNEL） technique and the pathological changes of bowenoid papulosis were observed by Hematoxylin-eosin-stained. Results Bowenoid papulosis exhibited disordered maturation and scattered, large, highly atypical cells mitoses throughout all layers of epitheliuml and there were few apoptotic cells in 5 normal skin tissuese and many apoptotic cells in bowenoid papuloses. The apoptotic index （27.1±15.1） in bowenoid papulosis patients was significantly higher than that in control group （6.8±3.5） （P〈0.01）. Conclusion Benign biologic behavior of bowenoid papulosis may have relationship with increase of apoptotic cells.

关 键 词：鲍温样丘疹病 细胞凋亡 

分 类 号：R739.5[医药卫生—肿瘤]