运动神经元病患者肺功能改变的临床研究  

Study of pulmonary function changes in patients with motor neuron disease

作　　者：华玲[1] 王利力[1] 刘玉祯[1] 袁学山[1] 周顺林[1] 张强胜[1] 

机构地区：[1]河北以岭医院,河北石家庄050091

出　　处：《中国现代医学杂志》2006年第10期1579-1581,共3页China Journal of Modern Medicine

摘　　要：目的探讨运动神经元病肺功能受损情况及病理生理原因。方法测定54例患者的肺功能并与正常对照组进行比较。结果患者通气功能明显减低(P<0.01),以限制性通气障碍为主要损害占70%以上,小气道受损约占60%,弥散功能受损占48.14%。结论运动神经元病患者肺功能损害以限制性通气障碍为主。其肺功能损害的病理生理是由于支配呼吸肌的神经元进行性减少,呼吸肌出现失神经萎缩,呼吸肌无力而出现一系列肺功能改变。[Objective] To explore the pathophysiological reasons for pulmonary function disturbance in patients with motor neuron diseases （MND）. [Methods] General pulmonary function of 54 MND patients was measured and the data were compared with that of the control group. [Results] Test showed that the ventilation function was re- duced remarkably with significant difference （P 〈0.01）. 74% of the patients showed restrictive ventilitory disorder, and 60% showed small airway function injuries, and 48.14% showed diffusion function injuries. [Conclusions] The most characteristic pulmonary function change in MND is the restrictive ventilitory disorder. The pathophysiogical mechanism for pulmonary function disturbance is because of the following： the neuron which steers the respiratory muscles gradually decreasing; the respiratory muscles atrophy and respiratory muscles asthenia appearing; a series changes of pulmonary function occurred.

关 键 词：运动神经元病 肺功能 限制性通气功能障碍 

分 类 号：R744.8[医药卫生—神经病学与精神病学]