儿童颅内恶性淋巴瘤9例分析  

Intracranial malignant lymphoma of children

作　　者：万大海[1] 罗世祺[1] 马振宇[1] 张玉琪[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科

出　　处：《山西医科大学学报》2006年第3期300-304,共5页Journal of Shanxi Medical University

摘　　要：目的分析儿童颅内恶性淋巴瘤的临床特点及治疗转归,以提高对此类少见疾病的认识. 方法回顾分析12年（1992～2004）手术病理证实的9例儿童颅内淋巴瘤临床资料. 结果儿童颅内恶性淋巴瘤包括原发性恶性淋巴瘤及颅骨淋巴瘤,前者多以颅内压增高症状起病,影像学表现为脑内等高信号、明显强化病灶;后者临床症状以头皮下肿物多见,影像学表现为颅骨破坏伴大块软组织肿块,伴明显强化;通过手术、放疗、化疗,但治疗效果不佳. 结论儿童颅内恶性淋巴瘤的临床及影像表现缺乏特异性,需手术或活检才可作出定性诊断.Objective To investigate the clinical findings, treatment and curative effect of the intracranial malignant lymphoma in children＇ patients. Methods The clinical data of 9 cases of intracranial malignant lymphoma were analysed. Results Intracra- nial malignant lymphoma included primary central nervous system lymphoma and lymphoma of skull The former usually presented with an increased intracranial pressure , showed solitary hyperdense masses of tumor with significant enhancement in the imaging examinations by CT and MRI. The symptoms and signs of the latter were painless scalp lump, the typical radiographic features include a large soft tissue component with expansion and destruction of the skull but less cortical destruction. The therapeutic effects were poor. Conclusions Patients with intracranial lymphoma usually do not present the characteristically clinical manifestations or findings in the imaging scanning. Biopsy or operation may be a method more reliable to confirm this disease.

关 键 词：淋巴瘤 颅内 中枢神经系统肿瘤 儿童 

分 类 号：R739.41[医药卫生—肿瘤]