DNA损伤修复基因XRCC3 Thr241Met多态与贲门癌、非贲门部胃癌易感性关系的病例对照研究  

DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to cardia and non-cardia gastric cancer:a case-control study

作　　者：黄贵培[1] 郑宗立 蔡琳[1] 

机构地区：[1]福建医科大学公共卫生学院,福州350004 [2]Department of Medical Epidemiology and Biostatistics Karolinska Institutet

出　　处：《中华流行病学杂志》2006年第5期420-423,共4页Chinese Journal of Epidemiology

基　　金：全国优秀博士学位论文专项资金资助项目(200157)福建省自然科学基金资助项目(C0410016)

摘　　要：目的探讨福建人群DNA损伤修复基因XRCC3 Thr241Met多态与贲门癌、非贲门部胃癌易感性的关系,分析基因与环境因素在癌症发生中的联合作用。方法采用共同对照组的病例对照研究方法,应用PCR-RFLP技术检测基因型,应用非条件logistic回归计算OR值及其95％CI。结果 XRCC3三种基因型(野生型CC、杂合突变型CT、纯合突变型TT)在贲门癌组的分布频率分别为43．2％、46．5％、10．3％;在非贲门部胃癌组的分布频率为53．2％、40．9％、5．8％;在对照组的分布频率分别为59．6％、35．1％、5．3％。经多因素分析结果显示携带变异基因型(CT+TT)个体罹患贲门癌的风险增加(OR=1．76,95％CI:1．07-2．90)。XRCC3变异基因型与饮酒、新鲜蔬菜摄入和慢性胃炎对贲门癌发生存在协同作用;与吸烟、慢性胃炎对非贲门部胃癌发生存在协同作用。结论 XRCC3基因多态与贲门癌发生有关,贲门癌与非贲门部胃癌的危险因素不尽相同。Objective To study the association between genetic polymorphisms of XRCC3 Thr241Met gene and susceptibility to gastric eardia and/non-cardia gastric cancer, and to investigate the combined effect between genes and surrounding environment. Methods A case-control study with respective control group was conducted. Genotypes were investigated by PCR-RFLP. Unconditional logistic regression mcvclels were used to estimate odd ratios （ OR s） and their 95 % confidence intervals （ 95 % CI ）. Results The frequency of XRCC3 CC, CT and TT genotypes were 43.2%, 46.5% and 10.3%, respectively in cardia cancer cases and 53.2 % ,40,9 % and 5.8 % respectively in non-cardia gastric cancer cases while 59.6%, 35.1%, 5,3%, respectively in control group. Variated genotypes （CT and TT） increased the risk of cardia cancer after adjusting for potential confounders （OR = 1.76,95% CI：1.07 2.90）. On eardla cancer risks, there seemed combined effects between varlated genotype and high rate of alcohol drinking, low intake of fresh vegetables and having chronic gastritis, Combined effects between variated genotype and smoking, having chronic gastritis were observed in non-gastric cancer group, Conclusion XRCC3 variated genotype was one of the risk factors of cardla cancer while different risks of factors might exsit between cardia and non-cardia gastric cancer.

关 键 词：胃肿瘤 DNA损伤修复基因 基因多态性 

分 类 号：R735.2[医药卫生—肿瘤]