乳头抽吸液的采集及影响因素分析  

Study on the nipple aspirate fluid collection and related factors

作　　者：高丹凝[1] 薛英威[2] 张秋娟[3] 李辉[1] 李康[1] 王滨有[1] 庞达[2] 赵亚双[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150081 [2]哈尔滨医科大学第三附属医院(黑龙江省肿瘤医院),黑龙江哈尔滨150040 [3]哈尔滨医科大学预防保健医院,黑龙江哈尔滨150001

出　　处：《疾病控制杂志》2006年第3期234-237,共4页Chinese Journal of Disease Control and Prevention

基　　金：黑龙江省自然科学基金(D0328);教育部回国人员基金

摘　　要：目的 描述黑龙江省女性乳头抽吸液的采集情况，分析影响乳头抽吸液采集的因素，为进一步研究其作为乳腺癌诊断方法的可行性提供依据。方法 经医生和受试者同意，采集乳头抽吸液并进行问卷调查，采用logistic回归法分析影响乳头抽吸液采集的因素。结果 乳头抽吸液的成功采集率为33．9％。乳腺癌患者与乳腺良性疾病患者及健康妇女乳头抽吸液的采集率无统计学差别（P=0．452）。单因素分析表明：①年龄在30～50岁之间；②初潮年龄早；③经产妇哺乳时间≥12个月；④湿性耵聍；⑤高脂肪饮食；⑥月经规律的妇女比绝经的妇女，乳头抽吸液成功采集率高（P〈0．05）。以年龄和身高体重指数作为混杂因素，多因素分析结果提示，初潮年龄早、哺乳时间长和湿性耳耵聍易采集到乳头抽吸液。结论 黑龙江省女性乳头抽吸液的成功采集率较低，样品的成功采集与受试者的年龄、月经史、哺乳史等因素有关。Objective To describe the situation of nipple aspirate fluid （NAF） in women in Heilongjiang, and to explore the feasibility of obtaining NAF in China in order to provide basis for further research on the diagnosis of breast cancer. Methods NAF of non-lactating women were collected and surveyed with questionnaire after consenting of physician and study subjects. Univarlate and multivariate logistic regression analysis were used to analyse the factors associated with obtaining NAF. Results NAF was produced in detectable amounts by 33.9% of all the subjects. No significant statistical different successfully obtained among healthy women, women with benign breast disease and breast cancer （P = 0. 452）. Univariate analysis showed that six factors were associated with increasing ability to obtain breast fluid, such as age up to 30 to 50 years （ OR = 2. 803, P = 0. 011）, earlier age at menarche （ OR = 1. 819, P = 0. 037）, long lasting time of breastfeeding （ OR = 1. 668, P = 0. 046）, women with wet cerumen （OR =3.548, P=0.000）, self-report dietary fat intake （OR = 1.698, P=0.030）, women with normal menstrual period （compared postmenopausal women）. Multivariate logistic analysis suggested earlier age at menarehe, （adjusted OR = 2. 076, P = 0. 030）, wet cerumen （adjusted OR = 3. 587, P=0.000） and longer breastfeeding （adjusted OR = 2. 075, P = 0. 011） may increase the ability to yield NAF. Conclusions In Heilongjiang province, the rate to obtain women＇s NAbs was low, which was related to age, menstrual, history of lactation etc.

关 键 词：乳腺肿瘤 抽吸 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]