维吾尔族2型糖尿病患者Calpain10基因分型及其环境影响因素  

Calpain 10 genetype of type 2 diabetes mellitus and environmental factors in Xinjiang Uygur population

作　　者：李琳琳[1] 张月明[2] 杜景玉[1] 毛新民[1] 冉新建[3] 王长辉 李念东[1] 孙晓风[5] 林仁勇[5] 杨永新[3] 

机构地区：[1]新疆医科大学药学院药理教研室,新疆乌鲁木齐830054 [2]新疆医科大学公卫学院营养教研室,新疆乌鲁木齐830054 [3]新疆医科大学基础医学院机能中心,新疆乌鲁木齐830054 [4]新疆乌鲁木齐市军区总医院口腔科,新疆乌鲁木齐830000 [5]新疆医科大学第一附属医院,新疆乌鲁木齐830091

出　　处：《疾病控制杂志》2006年第3期245-248,共4页Chinese Journal of Disease Control and Prevention

基　　金：国家自然科学基金(30160091)

摘　　要：目的探索Calpain10基因SNP43及部分环境因素对新疆地区维吾尔族T2DM易感性的影响。方法采用ARMS-PCR对54例T2DM患者和107例NGT人群Calpain10基因SNP43进行基因分型,并对部分环境因素进行logistic逐步回归分析。结果①与NGT组相比,SNP43的A等位基因频率升高。②文化程度高、动物内脏摄入量大、血胆固醇高与T2DM的发生呈正相关,而饮茶、水果摄入适中与其呈负相关。结论Calpain-10 SNP43 A等位基因可能与维吾尔族T2DM相关。文化程度高、动物内脏摄入量大、血胆固醇高等因素是维吾尔族T2DM发生的危险因素,饮茶、适量水果摄入是其发生的保护因素。Objective To explore the effect of single nucleotide polyraorphism 43 （SNP43） of Calpain 10 gene and part of environmental factors on T2DM in Xinjiang Uygur population. Methods The study samples consisted of 107 NGT and 54 T2DM of Uygur subjects. ARMS-PCR was used to determine the distribution of genotype and allele frequencies of SNP43 polymorphism （G/A）. The relationship between environmental factors and T2DM was analyzed by logistic stepwise regression. Results ①The frequencies of ＂A＂ allele was significantly increased as compared with that in NGT subjects,②Higher education level, high animal viscera intake and high cholesterol in blood were positive related to T2DM, while tea drinking and moderate fruit intake were negative related to T2DM. Conclusions ＂A＂ allele of the SNP43 in Calpain 10 gene may be associated with T2DM in Xinjiang Uygur population. High education level, high animal viscera intake and high cholesterol in blood might be risk factors of T2DM, while tea drinking and moderate fruit intake might play protective role in the development of T2DM.

关 键 词：环境 维吾尔族 糖尿病 非胰岛素依赖型 

分 类 号：R363.16[医药卫生—病理学] R587.1[医药卫生—基础医学]