亚硝化农肥水诱发鸡咽食管癌、胃癌和肝癌的病理形态学研究  

An Analysis of Patho-morphology of Chicken Carcinoma Model of Pharyngo-esophaged-stomach-liver Induced by Nitrosifid Farm Compost Water

作　　者：司建华[1] 谭家驹[1] 陈凤兰[1] 徐致祥[1] 徐冰南[1] 李广民[1] 吴校连[1] 杨胜利[1] 

机构地区：[1]广东省佛山市第一人民医院,528000

出　　处：《青海医药杂志》2006年第5期1-4,共4页Qinghai Medical Journal

基　　金：广东省自然科学基金资助项目(04008530);广东省医学科学研究基金资助项目(A1998646)

摘　　要：目的:分析亚硝化农肥水诱发鸡咽食管癌、胃癌和肝癌的病理形态。方法:具体试验方法见文献3,动物组织标本常规处理、病理切片,HE染色,光镜观察,并与高发区现场自然发生的鸡咽食管癌、胃癌、肝癌标本比较。结果:实验组100只鸡中诱出咽食管癌16例、腺胃癌5例、肝肿瘤3例,3个对照组无一例癌变。结论:模拟高发区现场、模拟鸡胃液诱出的鸡咽食管癌、胃癌和肝癌与高发区现场自然发生的鸡咽食管癌、胃癌、肝癌在病理形态上相似。Objective： To analyze the Patho-morphology of chicken carcinoma model of pharyngo- esophagal- stomach- liver induced by nitrosified farm compost water. Methods： 280 chickens were randomly divided into 4 groups： the experiment group, in which 100 chickens fed with compost water＋ NaNO2 by stomach tube. The other 180 were evenly randomized into 3 control groups （the control group, 60 each） and were fed with compost water, NaNO2 and tap water respctively in the same way. The farm compost was prepared with corn stalls, rice straws, excreta of men and livestock. The compost water, after being nitrosified and acidified, was fed through stomach tube 5-7.5ml/session, twice a week. Besides, a solution consisting of the respective formula of each group added with （3-4）L water with PH adjusted to（3-4） by 1N HCL was given and lib to all chickens in each group for 26.5 months. Results： in the experiment group, there were pharyngo-esophageal carcinoma 16, gastric edeno carcinoma 5 and liver carcinoma 3, in contrast to none in the 3 control groups, showing significant differences. Conclusions： It is similar that the phatho-morphology between induced chicken carcinoma model of pharyngo-esophageal -stomach-liver and chicken carcinoma at the some organs from the high morbidity areas.

关 键 词：食管肿瘤 肝肿瘤 胃肿瘤 鸡 农家肥料 

分 类 号：R735[医药卫生—肿瘤]