植酸抑癌动物实验初步观察  

Preliminary Study of Phytic Acid Inhibiting Carcinoma with Animal Experiments

作　　者：李国熊 许敬尧[1] 李英[1] 

机构地区：[1]杭州第一医院,浙江医科大学

出　　处：《河南肿瘤学杂志》1996年第1期14-16,共3页Henan Journal of Oncology

摘　　要：本实验观察到１％和２％植酸饮水能显著抑制ＮＩＨ小鼠移植性Ｓ１８０生长，其肿瘤抑制率分别为４０．０％～６３．０％和３７．８％～５１．９％，而植酸的水解物肌醇无抑癌效应。在二甲肼诱发ＩＣＲ小鼠大肠癌过程中，１％植酸饮水能使肿瘤浸润生长率和平均每只癌鼠癌灶面积分别从７０．０％和３．１７９８ｍｍ２下降到１０．０％和０．９０４０ｍｍ２，２％植酸饮水能使肿瘤发生率和浸润生长发生率分别从１００．０％和７０．０％下降到４２．９％和１４．３％。提示植酸抑癌不仅作用于起动阶段也作用于促进阶段。Our experiment results showed that the growth of S180 transplanted in NIH mice could be suppressed by 1% and 2% phytic acid(PA) drinking water. Their inhibiting rates were 40. 0%～63. 0% and 37. 8%～57. 9% respectively' But no inhibiting effects could be found by inositol,which is the hydrolysate of PA. In the carcinogenesis of colorectum induced by DMH in ICR mine,the infiltrating incidence of tumor and the average cancer area per tumor bearing animal could be reduced from 70. 0% and 3. 1798mm2 to 10. 0% and 0. 9040mm2 respectively by 1 %PA drinking water. And the incidence and infiltrating rate of tumor could be reduced from 100. 0% and 70. 0% to 42. 9% and 14. 3% respectively by 2%PA drinking water. This suggests the inhibiting of PA on carcinoma not only at the innation stage but at the promotion stage.

关 键 词：移植性S180 大肠癌 植酸饮水 实验性 

分 类 号：R735.34[医药卫生—肿瘤]